Most physicians have avoided CoolSculpting on patients with Raynaud's but this has not been studied. Theoretically, any disease or condition that cold weather would exacerbate was considered a relative contraindication, but patients with Raynaud's of their fingers and or toes would not necessarily be affected if the fat frozen by Zeltiq's CoolSculpting is in the abdomen or lovehandle region. As it has not been tested, we can't vouch for its safety, but this is something worth exploring scientifically, but I am not aware that Zeltiq is planning on doing so. Systemic diseases that can flare with cold temperature such as cold urticaria and cryoglobulinemia are a greater concern.