I have had 3 rounds of sculptra. One vile at each of the first 2 rounds and a third round in my lower face using 1/2 a vile. I didn't notice much difference after the first 2, but 3 weeks after the third round, my lower face started changing. At 5 weeks, I look puffy and my smile is different. I consulted a doctor in Chicago who suggested collagenase injections to remove the overfill. I am very unhappy with how I look and would like to know if this would work or if there is anything else to try.