25 y/o female, Caucasian - Microneedling before or after PDGF under eye treatment?

It is safe and reasonable to perform microneedling (not RF) one week before PDGF (Platelet-Derived Growth Factor) injections, and this sequence may even enhance the effects of the PDGF treatment.

Microneedling creates controlled micro-injuries that can increase skin permeability and may improve the absorption and efficacy of subsequent topical or injectable treatments, including growth factors like PDGF.

Combining microneedling with growth factor treatments (such as PRP or PDGF) is a common and effective approach in dermatology to enhance skin rejuvenation and healing.

A one-week interval between microneedling and PDGF injections is generally sufficient for the skin to recover from any transient erythema or irritation caused by microneedling. Most post-microneedling reactions (redness, mild swelling) resolve within a few days.

If you prefer to do microneedling after PDGF injections, it is advisable to wait at least 1–2 weeks after the injections to allow for optimal integration and effect of the PDGF, and to minimize any risk of local irritation or interference with the injected product.

In summary:
Microneedling one week before PDGF injections is safe and may improve treatment outcomes. If you choose to do microneedling after PDGF, wait at least 1–2 weeks post-injection. This approach is supported by current dermatologic practice and literature on combination therapies with microneedling and growth factors.