Androgenetic alopecia (aka androgen-related hair loss or female-pattern hair loss or hereditary hair thinning) is the most common cause of hair loss in women. However, there are numerous other important, and common causes, of hair loss that must be investigated in women. A proper history and physical exam will help determine the diagnosis for hair loss. A thorough review of a patient’s medical history (including medications, allergies, family history, and diet) is of utmost importance in identifying the cause of hair loss. A history of menses, pregnancy, and menopause is assessed. Specific hair-related questions that might be asked include: -When did the hair loss start? -Was the hair loss sudden in onset or gradual? If hair loss is sudden, there is likely a disruption of the hair cycle (telogen effluvium) whereas chronic (longstanding) hair loss may indicate an abnormality of the hair follicle (androgenetic alopecia). -Where have you noticed the most hair loss? When a patient presents for evaluation of hair loss, she may be referring to a single patch of alopecia (alopecia areata) or to extensive hair breakage from use of hair products (hair shaft damage). Patterned hair loss is seen most commonly in androgenetic alopecia -What is your normal hair care routine? Hair care practices and use of hair cosmetics (i.e. bleaching, permanent waving) can be key factors in determining the cause of hair loss. A detailed examination of the hair and scalp is performed with good lighting and magnification. Hair distribution over the rest of the body is also assessed to see if there is too little or too much hair in other areas. Certain labs can be quite helpful for determining the cause of female hair loss. Screening for thyroid abnormalities, low iron levels and anemia are important during a female hair loss evaluation. An iron panel and complete blood panel (CBC) are useful labs to obtain for women with heavy or long-lasting menses. For women with androgenetic alopecia, extensive hormonal evaluation (such as measuring testosterone levels) is usually NOT needed unless any of the following conditions are present: irregular menses, infertility, hirsutism (excess body hair), severe acne, or galactorrhea. In general, 4 labs that I routinely order in women with hair loss include: CBC, thyroid panel, Ferritin (to measure iron levels), and Vitamin D (which is essential for proper hair growth). Scalp biopsies can be used to make or confirm a diagnosis of alopecia and can be essential in guiding therapy. COMMON CAUSES FOR FEMALE HAIR LOSS 1. Androgenetic Alopecia (AGA), or hereditary hair thinning, is the most common form of hair loss in humans. This condition is also known as male-pattern hair loss or as female-pattern hair thinning. Onset may occur in either sex at any time after puberty and the majority of thinning occurs in the teens, 20s, and 30s. 2. The second most common cause of female hair loss is thyroid disease (either hypothyroidism or hyperthyroidism). Other common causes of hair loss include inadequate dietary protein, or low levels of vitamin D or iron. 3. Categories of drugs that may cause hair loss include: anticancer drugs, anticoagulant drugs, anticonvulsant drugs, beta blockers, tricyclic antidepressants, and oral contraceptives. Discontinuation of the medication is usually followed by hair regrowth. Oral contraceptives (birth control) must be selected carefully to avoid progestins with an androgenic effect. 4. Telogen Effluvium may cause sudden hair shedding. Common causes of Telogen Effluvium include high fever, childbirth, severe infections, severe chronic illness, major surgery, thyroid disorder, crash diets, inadequate protein, and certain drugs. The shedding often starts months after the inciting cause but is always self-limited and reversible if the offending cause is corrected or resolved. 5. Damage to the hair shaft by improper cosmetic techniques can cause hair breakage. There is little damage from normal dyeing, bleaching, waving or straightening. However, breakage can occur with too much tension during waving; waving solutions left on too long; or improperly neutralized, waving, and bleaching on the same day or too frequently. Other causes of hair breakage include excess tension in braids, ponytails, or cornrows. 6. Alopecia Areata is an autoimmune disease that affects almost 2% of the population in the United States. Inflammatory cells target the hair follicle, thus preventing hair growth. Typically a small round patch of hair is noticed; this patchy hair loss may regrow spontaneously. In other cases there can be extensive patchy hair loss, and in rare cases, there is loss of all scalp and body hair (Alopecia Areata Universalis). In summary, there are multiple causes for hair loss in women. In order to determine the exact cause of hair loss, a complete review of the patient’s medical history, detailed hair and scalp exam, and laboratory test(s) are necessary. Appropriate treatment and counseling can then be tailored to each patient’s needs.