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Posted underSpironolactone For Acne q&a

Does Spironolactone cause vaginal dryness?

nnikki625Mar 16, 2019
I am a 37 year old woman who has struggled with hormonal acne for the last 3 years. My dermatologist prescribed 50 mg of Spiralactone. I was on Spiralactone for 4 months when I began experiencing vaginal dryness. I also experienced late and light periods (I’m on the pill and have never experienced this). Is it possible Spiralactone is causing this issue?

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From board-certified doctors and trusted medical professionals
Dr. Laura A. Katz, MD
Board Certified OB-GYN
Answered on Sep 18, 2020
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Amy Y. Paul, DO, FAAD

Thanks for your question.  You might want to ask your dermatologist or prescriber if decreasing the dose is an option.   Some of my patients do fine on just 25mg daily without side effects, but found the 50mg too much.  If you decide the sprionolactone is absolutely not...

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Reuel Aspacio, MD, FAAD - Account Suspended

Hello and thank you for your question. In general, I recommend my patients to take the medication once a day at night. However, depending on the side effects experienced, the dosing and frequency may vary. I would recommend consulting your board certified dermatologist for evaluation of your...

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Laura A. Katz, MD

Spironolactone has a half life of about 16 hours for the active metabolites of the drug.  This means that it would take about 36 hours before traces of spironolactone should not be detected in your blood.  Hope this helps.

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