Thank you so much for your question! Before all else, I'd make sure you speak to your Mohs and/or Plastic Surgery team about their recommendations for anti-itching postop. That being said, I will often recommend a combination of Claritin during the day (non-drowsy) and Benadryl at night before bed (because of possible drowsiness) to help sooth itching at operative incisions. Depending on the location and time out from a procedure, applying ice packs to the site may also offer some relief. Lastly, hydrocortisone 1% cream can be used to help with itching and hives in general, but I recommend using this in places away from incision lines and also not on the face. I hope this helps, best of luck with your recovery! Peter A. Felice, MD