Depending on what condition of the lips you want, Botox may be of assistance in providing an appearance you desire. It will only last about three, maybe four months around the mouth at the most. As an off-label procedure, botox can be injected carefully and with only 1 to 2 units per site on the skin-colored upper and lower lip to help smoothen the vertical creases into which lipstick "bleeds". There may be a flattening of the lip and issues such as not being able to smile enough to show your upper teeth, and difficulty pronouncing certain letters, singing, orating, and playing a wind instrument.
The other aspect of perioral aesthetic improvement that Botox can accomplish, is by injecting the muscles that pull down on the corner of the lip (the DAO, depressor anguli oris), the corner of the mouth which curves down in many people as they age and gives a sad appearance, can lift up more horizontally. The DAO must be injected in the safer regions as doctors who have injected too high up near the corner of the mouth have found that unwanted relaxation of adjacent muscles have caused asymmetry of the mouth and problems smiling, which are temporary and come back to normal, but can take what seems like an endless four months, or so.