Botox with systemic mastocytosis, advice?

This is a really difficult question given the fact that system in systemic mastocytosis such a rare condition, and there simply is not going to be a lot of resources that can tell you if it is completely safe or not. If I were to inject you, I would call Allergan (the makers of Botox) and ask for input from their clinical physician team as they would have the most up to date data bank on complications and/or safety with this condition.  It takes a little bit of time to hear back from them, but they will get back to your provider with an answer.  All in all, Botox for cosmetic purposes is an ELECTIVE procedure, and not a life saving procedure. You would not want to proceed with it unless completely safe.  That being said, best of luck with this difficult issue.  Best, Dr. Giordano

From my experience I don't see why this should be a problem but I would recommend seeing a board certified dermatologist to see what is the best option for you. There may be other treatment options to consider such as Dysport or Xeomin.  Best, Dr. Emer

There should be no problem with either efficacy or interaction between the two but as always discuss any procedure with your primary care physician and be sure to see an experienced board certified dermatologist

Thanks for your question and as always we recommend that you have a consultation with a board certified dermatologist of plastic surgeon who are the true experts here. Under the right care and skills of a derm or plastic, this should not be a significant problem but one needs to proceed slowly and with caution with the proper provider.