In the over twenty-one years since I started using Botox for aesthetic reasons, I have seen a consistent trend that suggests that the earlier one starts, the slower the aging process.
It makes intuitive sense. Every day, we use our muscles of facial expression thousands of times--with each laugh, scowl or quizzical expression. Each time we do so, we potentially "etch" the skin with fine wrinkles, which, with time tend to grow deeper and wider. If we weaken these motions and soften the strength of the contractions with neuromodulators, like Botox, Dysport, and Xeomin, we potentially lessen over time the damaging effects of muscular movement on the skin above--the result: less wrinkling and less deep wrinkles. So, these days, I am more apt to treat younger patients, even in their early twenties, who complain of the beginning of crow's feet, worry lines or scowl lines.
A similar case may be made for the proactive use of fillers in very fine crinkles. Fillers not only diminish the depth of wrinkles, but have been found to stimulate new, native collagen production, both of which act against the age-related trend toward more pronounced wrinkling with the passage of time. Therefore, combining the use of fillers and neuromodulators makes good sense.