Biopsy After Freezing Mole?

i had a mole frozen off a week ago but doctor didnt do a biopsy, is there still a way to biopsy after to make sure its benign? thanks

Doctor Answers 6

Mole biopsy after freezing.

one week ago would be difficult. The inflammatory reaction could confuse pathologists and this could affect the diagnosis. I would wait until all of the healing is done and see if there is any part of the mole left. Otherewise I would watch the area on a regular basis and get check ups.

Bellevue Facial Plastic Surgeon
4.2 out of 5 stars 84 reviews

Mole biopsy

Please ask your doctor exactly what the lesion he removed was.  Seborrheic keratoses,  which are benign aging warty-looking growths, are usually treated successfully with liquid nitrogen.  If a true mole was treated with liquid nitrogen, it will probably regrow and can then be biopsied.

Martie Gidon, MD, FRCPC
Toronto Dermatologist
5.0 out of 5 stars 22 reviews

Frozen Mole

Most likely if your mole was treated with cryotherapy, it was not a mole at all but a seborrheic keratosis. This would be especially true if the mole was treated by a dermatologist. Many lay people will call a seborrheic keratosis a mole when it is not. We also hear them described as warts ( the British incidentally call them seborrheic warts). If there is a question whether a particular lesion is a seborrheic keratosis or mole, the use of a dermatoscope can easily differentiate the two.

Freezing tissue distorts the its histology so much that it usually can make identification very problematic. However, if there is a portion of the lesion still present after a month or so, you can always have this re-biopsied and submitted. Any anxiety over this lesion should be alleviated at that point.

Arnold R. Oppenheim, MD
Virginia Beach Dermatologist
4.7 out of 5 stars 14 reviews

Freezing mole

More commonly, seborrheic keratoses, or "age spots" are frozen, while nevi (moles) are biopsied.  Perhaps your physician froze a completely benign brown velvety seborrheic keratosis and not a mole.  Many times, it is dificult for a non-physician, or non-dermatologist to tell the difference.

Please see my blog post on the Kraussderm website to read about seborrheic keratoses.


Madeline Krauss, MD
Boston Dermatologic Surgeon
4.5 out of 5 stars 4 reviews


Moles  should always be excised and submitted for pathological examination. We can not afford missing a diagnosis of melanoma. With freezing, laser destruction or destruction of a mole by any means one misses the opportunity for a biobsy and proper diagnosis.

Samir Shureih, MD
Baltimore Plastic Surgeon
4.2 out of 5 stars 7 reviews

Biopsying a mole after it has been frozen

You should wait several weeks to preferably a month for the area to heal before having a biopsy done. A biopsy can then be done for any remaining portion of the mole for reassurance. I feel that it is never appropriate to freeze (cryosurgery) a mole or use a laser as the primary treatment for removing a mole. Regardless of how "benign" a mole may appear, a biopsy may still reveal it to be atypical. There are many ways to surgically remove a mole with a minimal scar and have tissue to send for microscopic examination which is the only way to ensure that it was benign. Other methods of destruction such as cryosurgery or a laser will alter its look and make it more difficult to observe for precancerous changes in the future.

Mitchell Schwartz, MD
South Burlington Dermatologic Surgeon
4.7 out of 5 stars 12 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.