Bellafill is the most studied filler available in the US. They have a 5 year safety study and working on a 10 year study. The results from the study show a granuloma rate of 1.7% but with treatment, that reduces to
Hello and thanks forposting.Bellafill contains PMMAmicrospheres and bovine collagen. PMMAis the permanent component of Bellafill. Bellafill is currently approved for naso-labial folds and acne scars,The PMMA does notmigrate, but the main safety issue with Bellafill in the risk of late granulomaformation. Granulomas are inflammatory nodules that may develop in the areas ofprevious injection of PMMA. The cause islikely related to an overly robust immune response to the PMMA – immune intolerance. When Bellafill was approved by the FDA, theymandated a 5 year post-marketing safety study. This study showed that there was a 1.7% risk of granuloma formation over5 years (17 of 1000 patients developed granulomas in this study). In myexperience, granulomas are a manageable problem – a series of injections oftriamcinolone and 5FU reliably shrinks the nodules down. There are also datafrom Europe and China suggesting that deep injection of PMMA onto bone furtherlessens the risk of granuloma because of the paucity of immunologic cells inthis anatomic location.I hope that thisinformation helps and best of luck to you!