Do Bellafill fillers cause granulomas/lumps and migrate over time?

Bellafill is the most studied filler available in the US. They have a 5 year safety study and working on a 10 year study. The results from the study show a granuloma rate of 1.7% but with treatment, that reduces to

Hello and thanks for
posting.
Bellafill contains PMMA
microspheres and bovine collagen.  PMMA
is the permanent component of Bellafill. 
Bellafill is currently approved for naso-labial folds and acne scars,
The PMMA does not
migrate, but the main safety issue with Bellafill in the risk of late granuloma
formation. Granulomas are inflammatory nodules that may develop in the areas of
previous injection of PMMA.  The cause is
likely related to an overly robust immune response to the PMMA – immune intolerance.  When Bellafill was approved by the FDA, they
mandated a 5 year post-marketing safety study. 
This study showed that there was a 1.7% risk of granuloma formation over
5 years (17 of 1000 patients developed granulomas in this study). In my
experience, granulomas are a manageable problem – a series of injections of
triamcinolone and 5FU reliably shrinks the nodules down. There are also data
from Europe and China suggesting that deep injection of PMMA onto bone further
lessens the risk of granuloma because of the paucity of immunologic cells in
this anatomic location.
I hope that this
information helps and best of luck to you!