Can Botox Make Autoimmune Disease Worsen?

There is no evidence that I am aware of that links continued Botox use and the stimulation of autoimmune diseases, including Lupus. I don’t see any similarity between the antigen of Lupus (the molecular structure to which the body attacks via antibodies) and Botox.

Mariano,
Botox does not cause autoimmune disease. It is more likely in your case to be a coincidence rather than a cause. It sounds like you are seeing the right doctors. Good luck with your progress.

First, I hope that now you have been diagnosed with Lupus and can get appropriate treatment, you will feel better. There is currently no evidence that treatment with botulinum toxin A causes any autoimmune diseases. Know that there is now a 20-year history of treatment with Botulinum toxin A.
Last year something like 4 million treatments were done. WIth these kind of numbers, if Botulinum toxin A did cause an autoimmune disease, there would likely be evidence to support this idea. There is not. In fact, botulinum toxin A is used to help focal spasms associated with multiple sclerosis, an autoimmune disease affecting the nervous system.
I would recommend following the advice of your rheumatologist regarding treatment for your lupus. Also, while it is easy to tell someone to get treatment for depression, recognize that one can become depressed when every day you don't feel right and no one seems to have an answer for what is causing the problem.
I would encourage you to monitor you feelings and consider that you may also have a mild chronic depression. This type of problem is best assessed by a psychiatrist who should spend enough time talking with you to decide if you are depressed or not. Again don't get a treatment if you don't have a problem but do get the help you need. Good luck and feel better soon.