You may decide you are okay with how you look after weight loss if any substantial weight loss is your goal.Any heat based skin tightening works best on younger skin - that's a result of more capable collagen generation.If your interest in Thermage is for your face, you may well want to also investigate Ultherapy Lift. It's a deeper targeted treatment that has shown some pretty substantial improvement in jawline and neck contouring.In any event, whatever treatment you may choose would be more satisfying to you if you waited until you were at the weight you want to be. The skin envelope stretches to accommodate fat and when you lose the fat, there may be more skin than a nonsurgical treatment can impact well. It will depend to a great deal on your skin's elasticity.