Hello,Voluma is the latest product in the Juvederm line and is intended for deeper, longer lasting, volumizing of the face. It is made of hyaluronic acid, as are many other injectable fillers. Perlane is a similar product sold in the Restylane line of facial fillers. Most often when we speak of volumizing fillers we are speaking of filling hollow cheeks and temples. Voluma is the thickest of the fillers in the Juvederm line and is intended for sub-dermal injection (below the skin). Ultra Plus is thinner and intended for more superficial applications, generally used as a dermal filler (within the skin for creases). Finally the Ultra product is the thinnest for more superficial use yet. Ultra Plus can also be injected sub-dermal and would provide similar results to Voluma, however, Voluma is expected to last longer and hold its shape a bit better in those applications. Prior to the introduction of Voluma, most injectors would use Ultra Plus for both sub-dermal and dermal injections and many injectors still do. Allergan (the manufacturer) advertises that reasonable results should last 2 years. Aside from clinical trials, Voluma has only been available in the US for just over 2 years and as such the broader population of patients and doctors are just now able to start vouching for its longevity.