How and Where is Botox Metabolized?

Question

Through which channels is Botox metabolized? I have been trying to find a definitive answer on this, but can only find sources that say it is "probably" or "likely" metabolized in a certain way. How and where in the body is Botox metabolized?

Monika Soni, MD · Answer

Thank you for your question. Botox lasts about 3-4 months. Botox works by binding to nerve endings, preventing them from contracting. The body metabolizes Botox through the liver and kidney excretion. Other alternatives to Botox are Xeomin or Dysport. I recommend having a consultation with an expert to discuss your concerns and to determine the best treatment plan for you. Best of Luck!

Monica Halem, MD · Answer

Botox is injected subcutaneously into the area where the wrinkles are treated. The botox then binds to the local nerve endings preventing the nerve complex from working. In this way, the muscle in the area that normally responds to the impulse is prevented from contracting. In this way the wrinkles, which are formed from the movement of the muslces lying underneath the skin, are softened. The body metabolizes the botox like it would any chemical substance through the liver and kidney excretion. Dr. Halem

Mitchell Schwartz, MD - Account Suspended · Answer

Since you ask, neurotoxins such as Botox, Dysport and Xeomin produce their therapeutic effect by acting selectively on peripheral cholinergic motor nerve endings to inhibit the release of the neurotransmitter acetylcholine at the neuromuscular junction. On intramuscular injection at therapeutic doses they produce partial chemical denervation of the muscle, resulting in a localized reduction in muscle activity. This is a permanent reaction within the nerve ending so that Botox is eventually metabolized within the muscle in which it was injected.

How and Where is Botox Metabolized?

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