Topical finasteride - Do you have any opinions, thoughts on its efficacy or how well it could work theoretically?

Because of the potential for sexual side effects from oral finasteride (Propecia and generic forms), many patients and physicians are seeking an alternative to the FDA-approved version.  The good news is that there ARE some peer-reviewed studies are reporting that there is some efficacy with topical versions of finasteride (see below).  In addition, many of these studies also support the theory that there is a lower/absent load of finasteride in the serum, and lower/absent sexual side effects with topical finasteride. 

The benefits of oral finasteride are very well known and it would be foolish to think that a topical version wouldn’t have some positive effects. Are there risks? Sure. There are always risks with medications, whether they are FDA-approved, compounded or over-the-counter. As a physician, I try to be a problem-solver and seek out the advice of some very brilliant PCAB-accredited pharmacy compounding chemists when we want to reduce side effects or increase efficacy or both for our patients—like we have had done with Formula 82M Compounded Minoxidil for thousands of patients.  Let’s not forget that type-1 5AR is localized primarily in the scalp, so a topical scalp treatment with finasteride does make sense.



With whatever treatment we prescribe, follow-up cross-sectional bundle measurements (aka HairCheck) every 90 days are strongly recommended. Those measurements always determine the course of treatment in the medical management of hair loss. The most popular compounded topical finasteride we prescribe at Bauman Medical contains both minoxidil and finasteride and is called “Finoxidil 82F.” Remember that compounded medications, by default, are not FDA-approved so always discuss with your doctor the potential for known and unknown risks.References:





M Caserini, et. al.  A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers. International Journal of Clinical Pharmacology and Therapeutics, July 30, 2014 (1-8). doi:10.5414/CP202119





BS Chandrashekar, et. al. Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride. Indian Dermatol Online J. 2015 Jan-Feb; 6(1): 17-20. doi: 10.4103/2229-5178.148925





S Sheikh, et. al.  A new topical formulation of minoxidil and finasteride improves hair growth in men with androgenetic alopecia. J Clin Exp Dermatol Res 2015, 6:1. doi:10.4172/2155-9554.1000253





Z Hajheydari, et. al.  Comparing the therapeutic effects of finasteride gel and tablet in the treatment of androgenetic alopecia. Indian J Dermatol Venereol Leprol Jan-Feb 2009; 75(1):47-51.





F Mazzarella, et. al. Topical finasteride in the treatment of androgenetic alopecia: Preliminary evaluation after a 16-month therapy course. J Dermatol Treatment 1997;8:189-92.





Price VH, et. al. Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily. J Am Acad Dermatol 2002;46:517-23.





Shapiro J, Kaufman KD. Use of finasteride in the treatment of men with androgenetic alopecia (Male pattern hair loss). J Investig Dermatol Symp Proc 2003;8:20-3.

Topical finasteride may be used by some doctors but there is no evidence it actually works. It is also not FDA approved

It seems like the field of hair loss and hair restoration would benefit greatly from a prospective, randomized double blinded, placebo controlled study showing the effectiveness of a topically absorbed formula of Finasteride which has both effective penetration and stability.John Frank, MDNew YorkOhio

There are no peer reviewed articles about the efficacy, safety and reliability of topical finasteride. Hassan and Wong have done some work, but this is NOT FDA approved. That being said, there are numerous other meds that work and are not FDA approved, as well as FDA approved meds that did NOT work, and have have severe deleterious effects.My recommendation is to find someone that does compound it, get someone to write you a prescription to compound and try it--all compounding pharmacies have to meet minimum requirements in order TO compound meds, and anything topical will have significantly lower risks and side-effect profiles.Best.

You will find variable absorptions and DHT suppression because topical finasteride is compounded and each formulation is unique with different strengths of finasteride, and different solvents.  In our internal studies, a well compounded topical finasteride of .05-.1% concentration showed high absorption in our permeability studies at the dermal papilla level which is where the enzyme that converts testosterone to DHT is located and is the target for finasteride.  You will need to find a well-compounded solution that does not contain a high amount of propylene glycol for best efficacy. However, a good topical finasteride solution is a good alternative to the oral administration.