Best time to take Roaccutane?

Any treatment for acne is a slow and tedious process, and one must be patient to see results. As you mentioned, you are on a low dose Roaccutane (isotretinoin), and your acne may get worse before it gets better. The time of day you take your medication has no effect on your acne; however, what you eat with your medication does have an effect.  Isotretinoin requires fat molecules to be absorbed into the system; therefore, isotretinoin must be taken with a fatty meal for maximum absorption of the medication. All brands of isotretinoin must be taken with a fatty meal except for Absorica, which has a lipid component built into the medication. For any other questions or concerns, please consult with your dermatologist. Good luck.