How Long Do Retin A Side Effects Last?

Hi,
Retin-a comes in three strengths, 0.025%, 0.05%, and 0.1%.  It is best to start out at the lowest dose and work your way up to the 0.1% dose.  The burning, peeling and dryness should only last for a few days after each application.  When you apply the cream and no longer get a response, then it is time to switch to a stronger dose.  You can use the cream once the response subsides and work your way up to using it nightly.  (The cream should only be used at night because the active ingredients deactivate in sunlight.)   You don't need to take a break from the cream after months of use.  The cream can also be placed around the eyes to decrease fine lines and thicken the skin.  Hope that helps.  -Dr. Yovino

The major drawbacks to Retin-A (tretinoin) are local irritation and redness that can limit its use in some patients. Inflammation and peeling are experienced by most patients when they begin tretinoin therapy. Although these reactions subside after a few weeks, many patients will not tolerate the initial peeling and redness. These symptoms can be lessened by using mild cleansers and initially applying tretinoin cream every other night. Patient education regarding the proper use of tretinoin cream is important.