Préime DermaFacial: What You Need to Know

Written byMari MalcolmUpdated on May 19, 2025
You can trust RealSelf content to be unbiased and medically accurate. Learn more about our content standards.
Written byMari MalcolmUpdated on May 19, 2025
You can trust RealSelf content to be unbiased and medically accurate. Learn more about our content standards.

A Préime DermaFacial combines five technologies in one comprehensive treatment that can deeply cleanse, exfoliate, hydrate, tighten, and rejuvenate skin on the face, neck, and décolletage.

Dr. Anil Rajani, a physician in Portland, Oregon who specializes in aesthetics, was an early adopter of Préime. He says he's "been consistently impressed by how this system elevates medical facials to a new level" with "five powerful technologies—each targeting different layers of the skin—to cleanse, hydrate, tone, and firm while enhancing the delivery of active ingredients deep into tissue. The result? Smoother, brighter, more hydrated skin with that coveted ‘glass skin’ glow."

According to Dr. Rajani, it's not just the technology that sets Préime DermaFacial apart: it gives providers "the ability to customize treatments and prepare the skin for more advanced procedures." In fact, providers often recommend pairing a Préime DermaFacial with complementary treatments like laser resurfacing, polynucleotides, and exosomes, for an even more dramatic improvement in skin quality. "With tools like VibroX and CO₂ microbubbles driving oxygenation and absorption, we’re finally solving the long-standing challenge of effective ingredient penetration," explains Dr. Rajani. In his practice, this has been "a game-changer in results."

Each facial treatment involves a series of steps.

Here's what to expect.

  1. AquaB: First, your provider will use the spiral vacuum AquaB handpiece to cleanse and gently exfoliate, prepping your skin for what’s to come by removing impurities, dead skin cells, and excess sebum. This same handpiece also infuses the skin with customized solutions, to nourish and hydrate. 
  2. VibroX: Next up is microdermabrasion, paired with red LED light and vibrational energy. This combo further exfoliates, boosts blood circulation, and oxygenates the tissues via CO2 microbubbles for smoother, more radiant and evenly toned skin.
  3. MicroT: For this stage, your provider will employ microcurrent technology, sending tiny electrical currents into the facial muscles to improve contours and provide a subtle lift.
  4. Collagen+: Next, they’ll heat the deeper layers of the skin to around 39-42°C (102-107.6°F) with 1MHz radiofrequency (RF) energy to stimulate collagen and elastin regeneration. As it develops over time, new collagen and elastin subtly firms skin, reduces wrinkles, and improves elasticity.
  5. UltraB: Finally, your provider will use the high-frequency (1MHz) thermal ultrasound UltraB handpiece to help your skin better absorb the active ingredients in a customized blend of serums and active ingredients, to leave your skin deeply hydrated and glowing. 

You’ll see an improvement immediately afterward, but the best results come after a series of 3 or more treatments, spaced every 4 to 6 weeks. Some practices also recommend ongoing maintenance treatments to keep your skin looking smooth, firm, and vibrant. 

“Préime DermaFacial is one of my go-to treatments for achieving that healthy, dewy glow patients love, without any post-treatment redness or downtime," says Dr. Ashley Magovern, a board-certified dermatologic surgeon in Manhattan Beach, California. "Its five-in-one technology allows us to treat all layers of the skin in a single session, from deep hydration and exfoliation to skin tightening and enhanced ingredient absorption." Like Dr. Rajani, she also appreciates its customization options, which are "ideal for tailoring to each patient’s unique skin needs while delivering visible, radiant results.”

Gabby Garritano, founder of JECT medspas in NYC, is also a fan. She says Préime DermaFacial "complements our minimally invasive, holistic approach—allowing clients to seamlessly incorporate advanced skincare into their routines while achieving visible, lasting results." She praises it for "offering a versatile, results-driven treatment."

Pros

  • Compared to other advanced facials (looking at you, HydraFacial), Préime DermaFacial is a much more comprehensive treatment, with benefits that go beyond deep cleansing, exfoliation, and serum infusions. The additions of microdermabrasion, LED light, CO2 microbubbles, microcurrents, and RF energy all have the potential to deliver a more visible improvement for concerns like laxity, fine lines, and wrinkles.
  • A Préime DermaFacial is suitable for most skin types and can be tailored to your skin goals, from treating active acne to contouring cheekbones. 
  • Most people experience no downtime. Unless you have very sensitive skin, you should be able to go about your normal activities after each treatment. 

Cons 

  • The firming and lifting results of nonsurgical treatments like this one can’t compare to a surgical facelift, so keep your expectations reasonable. If you have moderate to severe sagging, a provider who also offers a range of more invasive options can give you a realistic idea of what will work best for your situation. 
  • Like other regenerative treatments, this one takes some time and commitment to see optimal results. You’ll see the best result several weeks or even months after a series of treatments, once new collagen and elastin has developed.

Most patients don’t experience side effects after a Préime DermaFacial, but it is possible to experience mild inflammation or swelling in the few hours post-treatment. People with sensitive skin might be more irritated than others, so if that’s a concern for you, talk with your provider about how to avoid it. 

To help reduce the chance of side effects, avoid these things for at least 48 hours afterward: 

  • Direct sun exposure
  • Strenuous exercise
  • Skincare with irritating ingredients (like retinols or acids)
  • Hot tubs, saunas, or especially steamy showers

Updated May 19, 2025


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