Johnson & Johnson kills Evolence, cosmetic wrinkle filler

A. Foley on 4 Nov 2009 at 8:34am

A division of Johson & Johnson, Ortho Dermatologics, sent out notice that Evolence--a wrinkle filler--was being taken off the market and the product is up for sale. The Ortho website for Evolence is said to be "under construction." 

Evolence has failed to gain traction in a market crowded with alternatives like Restylane and Juvederm. On patients have complained about Evolence results more than any comparable wrinkle treatment, with 35% saying Evolence was "worth it."

The recent Evolence posting by a patient complained about lumps:

"Ughh...I am so scared. Had two syringes of Evolence injected 4 days ago (nasolabial folds) and I have a hard bumpy line on one side with redness and the other side looks maybe 25% better but with red bumps...and it still hurts. I am feeling very disappointed and worried that those bumps and lumps will stay...I don't look better at all!!!"

The difficulty of injecting Evolence may have led to its demise in the aesthetics market.  Dermatologist Dr. Mary Lupo explains that "Evolence is a very stiff product...It also must be injected with a larger needle and requires a lot of massage to prevent lumping, so bruising is very likely. Lumping is a real possibility."  Lupo adds that patients should "Proceed with caution."