Hyperbaric Oxygen Therapy (HBOT) and wound healing: Advanced Techniques

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Normal wound healing proceeds through a sequence of steps involving inflammation, regeneration of connective tissue matrix, angiogenesis, and resurfacing. These steps are critically dependent upon the adequate availability of oxygen and perfusion.  When these processes are interrupted either by decreased perfusion (as is the case with random pattern flaps) or inadequate oxygen (such as in smokers) Hyperbaric Oxygen Treatment (HBOT) can reverse the progressive process of devitalization of tissue, control infection, and similar to the injury in full thickness burns, decrease the size of the zone of stasis, eliminate the zone of hyperemia, and may save some of the tissue in the zone of coagulation. HBOT assists in healing devitalized tissue, collagen production and angiogenesis (regeneration of blood supply).  HBOT can optimize wound perfusion, reduce the incidence of infection, and by increasing the local oxygen pressure, trigger the healing cascade.  HBOT increases the oxygen concentration in compromised hypoxic 

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San Antonio Plastic Surgeon