Hyaluronidase: Stories

I didn't want to believe that this stuff could actually melt your own tissue, but now that it has happened to me, I have to agreed with some of the others on the board. Ive gotten juvederm before for my lip/smoker lines. This particular time, the doc said he would try a different approach and it wouldn't change the shape of my lips with the injections, but it did! My lips looked so unnatural. This was right before Christmas. Everyone noticed my mouth was different. So, I waited a few weeks and absolutely hated it so I got the injection of hyaluronidase in the beginning of January. He thought my lips looked great and tried to talk me out of it, told me to just wait until it disappated on its own. But I said I hate what it looks like and I don't want to wait. Well...it killed me. I actually screamed in the office and I didn't care! He put the stuff right at the lip line on both sides of my top lip without numbing cream. It did get rid of most of the juvederm and my lips look ALMOST back to normal and the smoker lines didn't come back. My lips still looked slightly puffy though. Now....three months later, I can see my lips are uneven and the one side has a dent right above the lip on my right side, on top of the smoker lines starting to come back. The dent looks Like a big hollow that was never there before. The other side looks normal. My lips look terrible. I also have a dent and lump in the corner of my mouth on the same side. I am really pissed. He never had to use this crap on anyone before and I was the first. I asked him if this would dissolve my own tissue and he said NO Way! WELL....IT DID! NOW...I will never use this stuff again. I just hope that my mouth goes back to normal at some point. I won't go back to this doc for Juvederm injections. Is this permenant damage or will my own HA come back in this area at some point?? I love how these docs take it apond themselves to do what they want and not what the client / patient wants. Next time I get juvederm and I don't like the results I will just wait it out. I don't need dents and hollows MAN MADE on my face!

so you had a bad experience. you're one in a billion who have. sorry but...... it was a bad choice for you and now ? . Dont sue the Dr..... If what you're saying is even true. Many Drs are losing business due to the use of HA dermal fillers. Some may even go as far as to make bogus claims that the product is dangerous when in fact its not. Even make the same bogus claims you are referring to.

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More disappointing news...I think they tell you to wait a year to see if the natural HA regenerates because apparently, the statue of limitations on filing a law suit for malpractice is a year! How evil!

Sorry to hear about all you guys who has a bad experience with fillers.

Hi... I had Hyalurondase to remove filler in my top lip line, I feel it has reuined my lips I have indents in the place where the filler once was, and the skin above my top lip as shagged. I do want to add that I noticed a small indent before I decided to have Hyalurondise. The body of my lips feel like empty sacks when I press down on it seems like it lost its bounce. I'm really worried the skin won't ever restore itself. This have left me depressed.

I asked friends and family they seem to think it looks normal as it was before the filler, but I can see the difference. I also went to the doctors and she thinks my lips look fine. My friend think am mentally scared by the whole thing and yes I think I am.

Please can anyone help me is it possible for the skin around and in my top lip improve in time I have read Hyaluronadase does not course permanent damage but yes temporary. I don't know what to believe I lost trust.

Hi jennifer 6778 thank you for your comment it was very kind of you and your comments.Yes i did think of lyme disease at one point but the filler has now been located in my eyes it has caused corrosion of both corneas so it is slowly burrning through my eyes.It is also burning the front of my forehead and behind my forehead i have been trying for months to get a pet scaan to see if it has reached1 my brain.I have been so il,i have now lost 4 stone i have not slept in 5 months and am so weak i can just about get dressed.My brain feels like it is suffocating i have burning continuously in the front areas of my face i have been to so many hospitals and they just take blood tests and send me home.It is becoming hard for me to breathe as my body is so weak.My brain is hardly functioning now i am forgetting peoples names.I have spent so much time away from my family because of this friends ignore me as i look so sick and cant even hold a conversation with them anymore i cant concentrate my brain isnt working properly.I miss my old life,i cant play with my kids as im too weak.I want this chemical out of my eyes and head but how, now they have found it in my eyes scares me that obviously it has migrated there so i know for sure it has passed into my brain i have felt it every step of the way.It has caused such severe symptoms i cannot even begin to describe how horrible this nightmare has been.It has also attacked my central nervous system causing muscle weakness burning in my shoulders,arms,back of neck.My head and brain feels like it is on fire i a slowly dying my body cannot cope my breathing is shallow now all the time i am so scared and no hospital will take notice apart from the eye hospital i am back there tomorrow to see how much damage has been done even now my eyes, forehead and brain are burning it is unbearable i cant take it anymore.The pain never stops 24 hours a day i am vomiting and shaking all the time and my skin looks yellow.I pray a doctor will listen and help me i cant go on like this everyday it gets worse and worse no one deserves this hell my life as i knew it has gone i still cannot watch tv, read, make dinner, chat, laugh,sleep,nothing.Its all gone i am not me anymore.Christmas and new year i was so sick it was horrible i need just someone to do something to help medically with theses symptoms or i dont kn ow what will happen.I regret every second of this filler nightmare,i have paid doctors to try to get answers but they just take my money and say it is not possible,buy it is i am suffering everyday i want out of this but i have just been left like this for god knows how long.I pray for the day this ends i just want to sleep again and not have burning everywhere that no one can see but i can feel insessantly.I hope i get help if i can manage i will let you know what is happening havent been on here for a while,cant concentrate too much,thank you for all your comments.Kxx

Hi there Mario thank you for your comments,and thoughtful coping strategys for this juvederm nightmare.I know my surfing the internet for explanations to the symptoms i am experiencing may sound a little excessive but these symptoms are very real and debilitating.You mentioned Mario speaking to someone who had similar brain fog symptoms as myself,did this person have filler between the eyebrows like me if you dont mind me asking.It is not just brain fog that i have been experiencing but severe memory loss too which is scary and burning in the head and eyes,also now pain in hips and joints.I truly appreciate your comments and will try to keep feeling positive but it is so hard when i dont know what i am doing wading through this intolerable brain fog it gets worse at night.I have this constant feeling of my head being clogged with a heaviness that consistantly burns its there 24 hours a day even after 4 months.I dont know if i could 9 months of this if that is how long it may take.Iknow sometimes the internet can put misleading stories out there but i just want to feel better,my whole body aches and i cannot sleep even all night,this is terrifying.Thanks for all your comments it helps to have someone there who doesn't think you are a whack job or making symptoms up,i am trying to eat a bit more as the nausea has subsided a little but i am still losindg weight 2 and a half stone in 3 months,i guess this doesn't help.Please keep chatting its nice to chat.Take care Mario,thanks again for all your advice.Kx.

Katie...What i would do is try to change the way you are percieving all of this.. as i think a lot of your symptoms are caused by stress and anxiety as the mind is very powerful (placebo effect) and can produce a lot of the symptoms you mentioned.

I would also advise to do less research on the internet as this will only increase your anxiety further, i actually spoke to someone who had similar side effects from fillers and had brain fog and many symptoms you describe and now 9 months later shes 90 percent back to normal due to the fillers dissolving naturally.

I think in time you will definitely return to normal as the fillers will dissolve naturally, in the meantime try to live your life like you used to even if you have to force yourself and do something fun or exciting.

I would definitely try yoga or tai-chi classes as these can be really helpfull in making you relax and are also beneficial for your health..please dont be victim of high stress as it can take over your life and make you feel ill and cause potential health problems in the long run.

Keep smiling and speak to ya soon :)

Mario

Thanks for your kind advice yes i have tried everything to sleep,all kinds of medication.Thank you for reading my very long description of current symptoms.I have decided to go to another hospital a&e dept in a hope that some doctor or test will show something i feel that filler should never be used in the glabella area as even another plastic surgeon i visited when i started having symptoms who performed nasal surgery on me 12 years ago said he never uses juvederm because it moves from where you inject it.I was going to have the injections done with him but his secretary didn't contact me back to say when his next clinic was on, so i went near to where i live,i wish i had tried to contact him back again i probably wouldn't be in this mess now.I know it is just looking back in retrospect now,but i am so angry as i have a family to think of.I agree with you bd55 i would wait out the filler if you are not having too many symptoms that are severe.I still have filler in my cheeks even though i had burning initially but after steroids it dispersed a bit it's just the symptoms now in my head that are worrying.I will keep trying to fight it what else can i do.Hopefully chat again soon.kx.

Katie, I'm so sorry to hear about the horrible time you are having and all the different symptoms. You mentioned not sleeping much the last 4 months. Have you tried any OTC or prescription sleep aides as severe lack of sleep is also contributing to your anxiety and stress level. Yoga is also a good stress reliever that I have started again in just the last few weeks due to my increased anxiety from having this procedure. After hearing about reactions some have had with hyaluroidase I am going to just wait it out. I am too afraid to inject anything else in this area especially if it could make things worse. My numbness is mostly gone and the fogginess has improved a lot. One of my eyes actually looks great and the only issue with the other one is that there is a light half-moon like shape that is visible. It is more noticeable in certain light and not so much in others. Has anyone had this experience? I believe I read of someone else who had it and she said it resolved after a few months. I hope you start to feel better Katie. You need to believe that things will improve with time. Try anything that can take your mind off it and help you to relax. I was so totally focused on it that it increased my stress level even more. I'd like to hear experiences from people who have waited for it to resorb and how they looked after.

Hi there Mario and bd55, sorry for the late reply,have been really unwell so not been on here much,yes i too have researched side effects of this filler and the only thing i could find was that botox can possibly cross the blood brain barrier and cause neurological symptoms for up six months after injections into the brains of rats.So my queation would be if botox can migrate to other areas as has also been shown why can't filler?This is scary as juvederm is a different composition than botox and just paralyzes muscles and eventually wears off.I did find one article by a doctor that said if filler migrated into eyes you will go blind and if it passes into the brain it can cause severe neurological problems.I also found an article about rabbits being injected via the spine with hyaluronic acid most had no side effects but 2 suffered neurological side effects as the acid managed to penetrate the blood brain barrier.Apparantly some peoples blood brain barrier is not intact due to injury or not properly developed so substances that are lipid in composition i.e.containing water can readily pass through,juvederm attracts water and hyaluronic acid is suppose to be natural in your body,but not when it is cross linked with a bacteria such as streptococcus equi which is apparantly non contagious in humans but causes a disease caused srangles in horses.It is scary stuff when you look it up and i have had it injected into my forehead.All this i found out after i had these injections,at no point during my consultation with the dermatologist who administered the injections did he advice me of any danger of having this chemical injected near my eyes if i was even slightly aware i would have ran out of there as fast as i could.He basically administered the hyaluronidase which did nothing as i already knew by then the filler had migrated,all it did was dissolve two lumps either side of my eyes that had been left after being injected for crows feet.I feel hyaluronidase basically is ok for small lumps on cheeks etc but not near eyes as i feel it causes your own tissue to disintergrate or collagen,my forehead seems to have a depressed area when i raise my eyebrows almost as if the fat has melted and there is just the skin left covering the bone which is tight and hard when i frown.I now have burning headaches in my forehead, severe brain fog that starts in the morning about about 10 minutes from when i get up after maybe 2 hours sleep a night for 4 months now.Still losing weight,am so sick of this my memory is so bad,i have asked my doctor to send me for a pet or spect scan to check for chemical changes in brain function but he wont as he says that is for dementia or toxic brain encephalopathy which he doesnt feel i have symptoms of.I even paid £200 to see a private neurologist funnily the one that discharged me from hospital with headaches,he holds private appointments as well,he saw me for 10 mintues gave me a prescription for antidepressants and told me to make an nhs appointment to see him,i have made one to see someone else but thats in december.My eyesight is getting worse i can barely see clearly in dim light i am squinting all the time when at home at night from the lights.I think my doctor thinks i am imagining these symptoms even though i look ill,pale and thin.My legs and back have started to ache affecting my walking,i know that a pet scan will show some damage i can feel this stuff has migrated, i wake up with a heavy feeling in my forehead like it is clogged up and now my eyes are burning the other night i cried and my tears burnt mt cheek,this was very scary they turned white and crusty then pink marks appeared and were sore.I told my doctor this he looked at me as if i was nuts.These symptoms are real they are happening to me i have never experienced anything like this before in my life i was perfectly well before all this.The doctor who done the injections hasnt even contacted me to ask how i am i am just left to deal with these debilitating symptoms that get worse everyday.I get very short periods when i almost feel like me and feel so angry that i let this happen just for a few lines in my forehead.Then the foggy head comes and i am lost in this all day trying to concentrate on doing normal things that were so easy before.I dont know who could help if this stuff has migrated how do you get it out of head.I was even charged £50 more for this juvederm instead of botox, what a joke.This stuff hasnt been tested enough for side effects especially not in the forehead or eye area,i suppose if you put any kind of acid on yopur skin or near your eyes it will burn so if you inject it under your skin whats it going to do?It may be a small amount of acid but even a small amount near eyes and your brain if it reaches there will do damage these are not deep fatty tissue areas they are delicate organs.I also read on a site of a qualified doctor testing raw chemicals in a laboratory who accidentally spilt a very small amount of a toxic material on her hand which was gloved and even though it did not burn her the chemical got into her system spreading into her brain causing the chemical to basically eat away at her brain tissue,she died 5 months later aged 42,proving how dangerous chemicals are wether in raw form or crosslinked.Juvederm is only meant for deep tissue,not to be injected into a muscle as stated on the juvederm website.Amazing what you can find out if you look hard enough.Please forgive my long ranting again but there should be more widely accessible information out there,i will keep pushing for help i pray there is one professional person out there that can help,i cant even get to see a toxicologist,my doctor said he cant refer me,if i could only get this stuff out of my eyes and forehead i may feel normal again.I dont mean to frighten anyone,but this has happened to me.I know how you are feeling db55 hopefully your symptoms will go as you had the injections under your eyes not above and they were probably done just under the skin so no muscle was touched mine was done into the muscles of the forehead like botox is supposed to be for.I should have realised when the injector said he did 15 botox injections a day and filler maybe once a month that botox is more safe and widely used.Funny when i went back to see him again after having symptoms he said he did use filler in the forhead but only after botox first so why do it to me?Most doctors on sughts say do not use filler in the forehead or near eyes,on the fda sight which i have joined, about complaints of dermal fillers there is a few people who have complained about blurred vision after injections in the tear trough area,one man was really ill,and two people had it in the forehead but had hyaluronidase quickly i didnt,i wish i had maybe it woul have dissolved the filler before it spread to my eyes and possibly inside my head.I would say maybe db55 speak to the injector if you are feeling unwell,ask me anything you like i will try and answer you as best as i can or advice, dont suffer go back,complain,hyaluronidase may help in your situation.Let me know what you choose to do if you like,and keep in touch Mario,its nice to hear from you all i appreciate all your feedback.I will keep you all up to date as much as i can,all the best to you all,keep well.Kx

Hi kate...you are not boring or scaring ;)

Trust me this will get better as the fillers will eventually metabolise out of your system.

I just wanted to ask you ..Is this toxic side effect you are suffering common in dermal filler treatments or rare as i havent done alot of research into filler side effects as most seem to just suffer from lumps or swelling ?

Also have you been given any clear answers as to why you are suffering these terrible side effects also what has the original dr who treated you done about this?

Mario

Hi there Mario and my dear Simba thank you both very much for your comments.Yes i wish Mario that i could just turn back time and not bothered with the few(not very noticable wrinkles)i had between my eyebrows.Or wanting just a bit more fullness in the cheeks for my wedding.I have had surgery on my eyes 9 years ago,and a rhynoplasty 13 years ago,i also have an implant in my upper lip.But they were a walk in the park compared to the symptoms of this filler.I am now so ill i cant remember what day it is most of the time.The feelings that i experienced in the hospital of this stuff movig around would scare alot of people,it scared me.This is probably the only place i can express what i have experienced as alot of people have had side effects.I now have almost permanent brain fog,severe headache,nausea i dont go to the toilet for days,any medication does not help.My gp was going to send me for a spect scan he(i was paying for this privately)referred me but didnt state why i needed testing and that i requested the scan,so the private diagnostic centre wont do it.I have now booked myself with a private neurologist who just happened to be the doctor who discharged me from the nhs hospital,he just happened to have a consulting day at this private clinic.It will be nice to see if he acts any different when i am paying for his services.I could have seen another doctor but when i heard the receptionist say his name on the phone i thought why not,atleast he knows my history.I know as you say Mario my physical health is suffering,i have no energy,am out of breath,and am taking too many painkillers daily.I can feel the filler in the front of my head,i know this sounds maybe impossible but it feels like there is something covering the inside of my head.My hearing is now suffering,the tinnitus is constant,i have never had fillers before and was nervous too of trying new things.It is all advertised as being so easy and natural,and i was so gullible,now i am stuck in this torment.I am really believeing now that if this stuff has migrated it is stuck doing irreversible damage and i cant do anything about it as no doctor is listening to me.How could you possibly expel something from your head.This is the stuff of nightmares.Everyday is like groundhog day i am so depressed just waiting to see what symptom comes up next throughout the day.I can just about hold a conversation now without forgetting information.All this from a filler suppose to make you look better.I look like a 50 year old who has gone through major trauma and it shows on my face.I cant even look at myself anymore,mainly due to anger,frustration,self loathing,guilt and cause i am scared i dont recognise myself anymore.I am a shadow of my former self literally.I would give anything just to be healthy again and enjoy life as before.The only thing keeping me going is my family.Thank you for your kind words Simba i am so happy you are almost out of this nightmare,its been almost 3 months for me,the cheeks dont bother me much,i can still feel the filler in there.I know this has affected my central nervous system as well.I am getting numbness in my fingers and my legs feel light almost as if there floating and my hands tremble.I feel that this is taking its toll on me and i dont how long i can put up with this constant myriad of debilitating symptoms,i've even looked into stem cell research for damage to brain cells through toxic encephalophathy.It's alot of money but when you are desperate to feel better you look into anything.Please again forgive my prolonged rant,i am so fed up of i dont even speak to people about it as i know theyd think it was weird.If i knew that these symptoms would pass like botox id be happy there was hope but i have not come across anyone in this situation yet or who has been and thats scary.I want to scream please someone help but because you look half normal people think you are imagining it.I will keep you updated if you like as long as i dont scare you away or bore you.You have all been warm and kind with your comments and it helps me to feel some sort of normality that i am not alone as sometimes i do feel that way.Please keep forwarding your messages to me it is great to hear from you,let me know Simba how things are going for you you have helped me imensely.Please anyone thinking of having dermal fillers do your research check everything thoroughly,i wish i had looked into fillers more then i would never have had them in the forehead.The best wishes to you all.Keep well.Kxx