I have exactly the same "dents" as the man in the picture above. The truth is, doctors don't seem to know what they really are at all. They have been there since childhood, just as everyone else I've met with the same issue. So you see, they are not caused by aging falling fat pads. We were born with these. I have tried juviderm, radiesse etc. multiple times with zero effectiveness. You see, there is connective tissue along the crease that is pinning that tissue down... It is very difficult to pinch. Fillers will fall either above or below that connective tissue, thus emphasizing the crease. Fillers only help until the swelling goes down, and the following week they look worse than to begin with.
The best results I've ever had was from a Dr. that actually put 2 needles in simultaneously and worked them around to break up that connective tissue, then filled the same with restalyn in an attempt to keep the tissue from reconnecting. The restalyn wore off, and the tissue reconnected, but the results lasted about 3 months.