My Story - New York, NY

Ten years ago I had a consultation with plastic...

Ten years ago I had a consultation with plastic surgeon for a procedure. While determining if the procedure was a good choice the doctor suggested that I get a filler called Restylane for under my eyes. He said it would help my tired look and fill in the hollow circles under my eyes. While I didn’t go to him for this issue I did agree that it may be a good idea. He said it was safe and would benefit me. I had just turned 40 and thought this would hold back the hands of time.

That is when I started with these injections. I did go to a few different dermatologists and plastic surgeons throughout the years and never had an issue. I tried Juvederm, but I didn’t like the effects, it caused a blue hue under my eyes.

Two years ago a friend of mine recommended a dermatologist that she was going to who is board certified and had performed 1,000’s of injections. He dissolved the Juvederm immediately and said it wasn’t injected properly which is why I had this blue hue and a bag was forming under my eye.

He waited two months before he injected me with Restylane. Before I had gone to him I had extensive dental work which also caused me some sinus issues.

A few months after the injection I noticed some red swelling under one eye. I called my dermatologist and informed him of this issue. He said that I probably was allergic to some topical eye cream I was using. He said if it was the Restylane, I would have had the reaction immediately. He told me he needed to see the swelling to determine what it was. The swelling only lasted for a day or two and happened so infrequently that by the time I made the appointment the swelling was gone. So I started taking pictures. I showed the picture to my dermatologist and again he said it was from topical creams, so I threw out all of my expensive anti-aging eye creams, face creams, etc. I started using cetaphil cream.

July of 2013 I had my yearly injection of Restylane. At the end of August I noticed some swelling for a day or two. Then over the course of the next few weeks the swelling started every week and would last for three days. By October the swelling became severe. I went to see my primary care doctor finally a doctor witness the actually swelling. She gave me antibiotics and said I had a skin infection and it should be cleared up in a week. Two weeks after the first antibiotics the swelling came back under both eyes and cheeks. I immediately went back to my primary care physician. At this appointment she didn’t think it was a skin infection, but either an allergy or a sinus related issue. I made an appointment with an allergist who took a series of blood tests and a sinus scope. He said I had a low grade sinus infection, but thought this issue was from my immune system. All of my tests came back negative. I informed both doctors that I was injected with Restylane and they both said that it definitely wasn’t caused by Restylane, that I would have gotten this reaction immediately.

I started researching this on the internet and found other people with the same exact issue as me. I also work for a medical education company who teaches physician’s how to inject these products. After speaking with my boss she told me this reaction could be caused by a biofilm infection and could have spread from the dental work I had done. There was a faculty meeting just a month prior discussing this topic.

I truly believe that it’s not the fault of the injector or the product, but the fact that I may have already had some sort of infection. Once I was injected it may have disturbed the infection which attached to the Restylane.

I went back to my dermatologist with this information. He had never seen a case like this before and was shocked when he saw the pictures and then saw my swelling first hand. He dissolved the Restylane and immediately put me on 500 milligrams of Biaxan twice a day for 5 weeks. For three weeks I didn’t get any flare ups, but became very sick from the antibiotic. I was just approaching my last week of the antibiotics when the swelling returned and it was severe. I got violently ill from the antibiotics and couldn’t hold down any food. I went back to the doctor this past Tuesday and he reinjected me with the solution to dissolve any remaining Restylane. He put me on a new antibiotic for 30 – 60 days depending on how I can handle it.

It’s been two weeks since the Restylane was dissolved for the second time and I have been fine until today, January 22. I missed one antibiotic and already see swelling under my eye. I have another two weeks of antibiotic so hopefully this will help. I will keep you updated.
New York, has your doctor told you that you have a biofilm infection? I had one caused by Restylane to the tear trough area. You can read my story here: http://www.realself.com/review/new-york-ny-disastrous-result-injecting-restylane-tear-troughs . I finally had eyelid surgery yesterday, and the surgeon, who is an expert in biofilm infections, told me there was still some remaining encapsulated Restylane, present after 15 months and after dissolving with hyaluronidase. Be sure to be persistent and get the proper treatment until your infection is cleared! Sadly the whole ordeal left my undereyes a mess, which is why I finally elected to have the surgery.
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Still Swelling Up

So I have been on four antibiotics and nothing is working. I have had the restylane dissolved twice. I saw my doctor January 28 and he suggested that I go back on the original antibiotic which made me sick, but I really don't have a choice. I have been swelling up everyday now. I have an appointment next week to try and dissolve any remaining product next week if I am not swollen. I have been on antibiotics for three months now, which I am very concerned about since this will cause stomach issues. I am posting a pictures of the swelling when this started. I have some new pic from this week that I will upload later this week.
Hi Sallify, Yes, I definitely have a biofilm infection. My doctor is trying so hard to help me, but I am still in bad shape. I have to go back on the original antibiotic once I'm finished with the current one. My eye and cheek swelled up so bad again last night, I don't know what else to do. He is going to dissolve it for a third time next week once the swelling goes down. Who is the doctor that is an expert in biofilm? I can't seem to find anyone who really understands this. Thank you Rose
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I am so sorry to hear what you're going through, Rose. I went through a similar hell for about six months, then was left with saggy, baggy uneven eyes. Rhoda Narins in New York is an expert in biofilm infections and their treatment. And the plastic surgeon who just removed the last of the encapsulated Restylane for me last week in L.A. is Dr. Kami Parsa. Here is a link to an article that Dr. Narins wrote on treating biofilms from fillers: http://dermatologytimes.modernmedicine.com/dermatology-times/news/modernmedicine/modern-medicine-feature-articles/biofilms-dermal-fillers-manag I haven't yet reported my infection to Medicis, the manufacturer of Restylane, but reading more and more stories here of women here who are having biofilm infections--diagnosed and undiagnosed--makes me think that all patients suffering these symptoms should report these symptoms/infections to the maker.
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So....from the research you've both done Sallify and NY is this infection something that you already HAD somewhere in the body that attaches to the artificial filler (could be Resty, Sculptra etc) and because of the properties of the filler becomes hard for the antibiotic to attack....OR is it that there has been bacteria introduced through a less-than-clean injection needle or injection site? Or do they think that the source of the infection is of less importance than the fact that the filler provides a host environment that makes it amost antibiotic immune.... btw...you too are providing a real resource to the RS site. thanks, grace60
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Getting Better

Well it's been some time since my last update. I have had the product dissolved three times now and went back on the Biaxin antibiotic. It's now been over four months on antibiotics. So far I'm good. I haven't swelled up since February 2nd. I have five more days on the antibiotics, once I'm done, hopefully I won't swell up again.
Hi, I am so very sorry to hear about your experience!! Thank you for publishing and getting more info out to all of us. You are a very beautiful lady. Hopefully this last round of antibiotics will do the trick for you. (Hope you are taking VERY HIGH doses of Probiotics!) I want to throw something out to you that may or may not have any affect on your swelling. I have had health issues in the past, and I now deal with swelling under my eyes into my cheek area. It is a mystery to my primary care physician as well as my dermatologist. I had Restylane injections to try to help my under eye circus. The injections did help me for my good days, but I still continue to have bad days. I have since learned (through trial/error) that eating sugar will absolutely guarantee a blow up under my eyes. I cannot eat any desserts or God-forbid, chocolate. I can tolerate a small piece of cake/muffin/cookie from time to time, but anything that is high is sugar, Forget It! Keep me posted on your progress. Positive thoughts coming your way!!
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Finally Better

Well there is light at the end of this tunnel. Since my last post I finished the antibiotics. It is now going on three weeks and haven't had any swelling at all. I am back to normal and working out again. My eyes look just fine and I would never get fillers again. Yes, it was great for a few years, but when the troubles begin I thought I would never get better or look normal again. I had a wonderful doctor who gave me full attention and didn't give up on me. He told me he would continue to use the solution to dissolve the product until it was gone, and it took three times. My advice, be aware of your health conditions, do research and ask a lot of questions. You may have a great doctor, but they don't know everything. You may think, this is just a filler, but a filler can cause serious issues and it's no longer worth it for me. I will just age gracefully and take care of myself. I am happy and healthy once again. I will post pictures of myself soon.
Congratulations! I hope that the biofilm infection is eradicated and that you never have problems with the swelling and inflammation again. You got the proper treatment: a long course of powerful antibiotics and dissolving the filler. There are still so many doctors injecting these fillers with no knowledge at all of the risk of biofilm infection or how to treat it. It's important that you shared your story here to enlighten those doctors and to help people who are having the same symptoms to get the proper treatment. I'll bet you've never been happier to get your old face back again!
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Spoke TOO Soon

I am sorry to report that I am back where I started. It was just three weeks that I finished my antibiotics and the swelling returned with a vengeance this past Friday. I was doing great and then I got fitted for glasses. They were a bit tight on the bridge of my nose and four days later I noticed a bump on the side of my nose and my face. A few hours later the swelling returned. I think the pressure from the glasses may have started the infection backup. I'm sure it would have come back but not this severe. I just went to the doctor this morning and I am back on antibiotics for another 3 months or longer. Once the swelling goes down he will inject the dissolving solution again. My doctor has a conference call with a few doctors this week to see what else needs to be done and how long I should really stay on the antibiotics. He is reaching out to a bunch of experts to see what their experience has been and how to get me well. I was in such bad shape yesterday that I couldn't go to work. This is very depressing, but I am going to keep positive and I know eventually I will get rid of this infection. My doctor also prescribed steroids because the swelling is severe and I can't stay like this. I will keep you posted.
NewYork 5025, do you have any current pictures?
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Will update pics this week
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Appointment with an Infectious Disease Specialist

My situation hasn't gotten any better and I must stay on the antibiotics. If I miss one day, the swelling starts. My appointment is May 13, and I am very anxious to find a solution to this problem. It's now been 7 months on antibiotics and very high doses of probiotics, lots of water and limited sugar. I'm not sure what else to do, but I am hopefully. Will update pics and status.
Oh, no, this is terrible! My symptoms (mostly) cleared up after six weeks of antibiotics. Is your doctor sure that your symptoms are caused by a bacterial infection? Have you had a culture? I am so sorry that you've endured this for so long.
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It's May 7th and I am sure I can say, "We all are hoping that you are looking and feeling better." I used to take a thyroid replacement that contained either porcine or bovine thyroid material; I would break out in hives after consuming it and put two and two together to realize it was the animal hormone. I am almost wondering if you might have a bovine or porcine allergy. I believe the HA is made with one of those two.???? Looking forward to seeing your current pics.
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My update since May 13

I have been seeing a new physician and things have improved considerably. Since May 13 I had only one minor episode which didn't last long and didn't react as the past episodes of swelling, soreness, red bumps, etc. This lasted one day and the culture came back as a low grade bacterial infection, so it seems the infection isn't as strong. That episode was at end of June. I am no longer on antibiotics, and have been treated with 5FU. Three injections within three months. It seems to be kind of a protocol for quite a few physicians in the field of dermatology.

What I did: I contacted all the physicians that have injected me and requested my medial records as well as my dental records when this problem started, and put together a timeline from the last 7 years to figure out how I got this bacteria. This was a project but it's worth it, especially if helps the physicians understand and figure out what may have cause this.

You need to educate yourself, get the right physician who has treated this. Physicians are now seeing more of these cases so they are talking to each other to fix the problem and avoid the problem. Hopefully they ask their patients the right questions before they're injected.

The problem is the bacteria attaches itself to the product and makes a home there. It's difficult to get rid of the bacteria, so the product must be removed in order to not have a place for the bacteria to live on.

It's important that you educate yourself and read these physicians articles/abstracts. It will help you to find physicians who have had these cases and know how to treat them. Pubmed is a website that you can search for articles referencing "Facial Filler Complications". There is an article written by Daniel Cassuto, MD reviewing the filler protocols and treating complications. Its very informative and interesting. You need to know the physician who is treating knows what they're doing. You will get rid of this bacteria with the right treatment for you, but some times it takes many months to over a year to resolve. It really depends how you went untreated and the reason that you got the bacteria.

There have been cases reported with the following ways that the bacteria may have been contracted. One is dental working including cleanings right before or after being injected, any type of minor surgery done on the face near the time of injection, contaminated products, the physician not injecting properly and non-sterile prep prior to injection. There is a protocol on how the physician should prep you before the injection. There is also a protocol on the direction of the injection as well as amount that should be used. There are many factors, but you must be diligent in order to get better. Too many physicians are not educated about this problem, and they are dismissing that this problem is related to fillers.

I really feel hopeful this time that I'm going to get better. I hope this information helps somebody.




Reasons you can
Hi, First i want to say that im sorry to hear about your event on biofilm infection, and hope the best for u. I want to tell you all, that i was just thinking about using restylane, which someone told me i could use. I got some problems with my look, i look much tired, and need some volume in my face, and by restylane i could get the solution ive been told. But after reading this topic, im very confused about this. What would you recommend me? Regards
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Thank you for sharing your journey. I'm very glad that you are healed.
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Ty for posting this. Had Dysport injected last Aug in forehead for very light wrinkles and 11's it made my face fall and tons more wrinkles. Went to see another Dr other day he tried to get me to inject fillers in my face to bring volume back. Of course sounded good and models looked great on brochures but scared bc I already ruined my face big time. After reading your bad experience I will refrain. Ty for posting and I'm sure it's been heck for you. As I'm going thru heck with losing my face.
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