I first had Radiesse for very deep frown lines (marionette?). People often told me I looked mad. One syringe of Radiesse did not much for me. A little bit better.
When I retured two weeks later for a check up, I had already decided I needed more. They talked me into Perlane saying it would last longer and fill the lines a little better. Boy did it. My mouth is now even across with no frowning. It took almost two syringes. It did hurt a little more. With Radiesse they put lidocaine in the syringe so it didn't really hurt. No lidocaine with the Perlane. I could feel it pushing up through the lines. Almost feeling a sort of poping sensation. It was a little uncomfortable.
I have had a clitoris piercing, tattoo on my ankle, and have had cortisone injections in my shoulder. I would put it right along those lines. Sorry, I didn't have any kids so I can't rate it against that. The pain afterwards was much less than with Radiesse. Hardly any bruising.
If you have really deep lines, I would recommend it.