“Scared About Reaction of Hyaluronidase with Own Collagen”

Hi, Was the name of the dr who you saw yesterday initials R M any chance ???

I am so happy for you that your nightmare seems to be coming to an end!!! The most amazing thing about your story is that you actually found someone who knew what they were doing to take care of you properly. I absolutely love a happy ending - let us know when it has resolved completely. Cheers

Hi Miriam. Please email me a picture of yourself and let me know who your doctor was. Please tell me the entire story of what happened to you, everything you know, including the product, cost, amount of product, what areas of your face were injected, what you discussed with your doctor, any actions done to correct the problem, how much medication was used to correct the problem (if any), etc. Everything you can remember, no matter how trivial you may find it. I am very concerned that your self esteem is so affected that you would even say you are contimplating suicide. I would appreciate it if you would email me privately so we can discuss your situation. If I can see you, perhaps I can refer you to someone who might help you. I am from Phoenix, AZ as well, but I am now in Saudi Arabia working with my husband, who is an MD. I wish I were there to look at you personally, but hopefully I can assist you somehow. I hope to hear from you.

Hi....please email me... I am about your age and did the same thing... I have thought about suicide many times as well and i know how much this has ruineddd my life..i am so ashamed too.. please email me/.

Lyn20 - I agree this is a horrible journey but we have to stick together and help each other. What exactly did you have done? How long ago? And what has the outcome been? Hang in there. It will get better. K

If you read between the lines of Dr Verret's reply - he essentially says "I don't know." The approval given in 1948 was not to inject hyaluronidase directly into the skin to dissolve dermal filler. It is still not FDA approved for this purpose. This an 'off label' use since about 2006. When Dr Verret says "there are no reports that I can find in the literature to indicate that it causes a clinically significant loss of native hyaluronic acid." It appears he means this in relation to its "on label" use as a dispersing agent. This a DIFFERENT APPLICATION to dissolving filler. No clinical trials have been undertaken about the effects of hyaluronidase on tissue when it is used to dissolve filler. In any event, not finding any reports in the literature does not mean it doesn't happen. The anecdotal reports and case studies are right here on RealSelf. And they say it DOES happen. I am gratified to see that Dr Verret knows some people are allergic to hyaluronidase (I wish my injector had known and warned me!) However, Dr Verret's doesn't really give an answer as to whether hyaluronidase dissolves any natural hyaluronic acid when used to dissolve filler. His response is vague and noncommittal. Most importantly, he does NOT ever say "Hyaluronidase does not affect natural tissue at all."

Hyaluronidase is a nightmare! Only 13% of RealSelf reviews say it was worth it... How are you doing now? Have things settled down? Is your face back to normal?

Hi TBF- I have good news and bad news. The good news is I'm about 99% recovered from my botox disaster. I think it took 11 mos! I still see the tinniest bit of muscle strain over my right eye but to anyone else it would appear to be back to normal. On the other hand, I'm still having some trouble from the hyaluronidase. I actually went to see another doctor last week to get his opinion. He said yes, it is technically possible to have some of your tissue dissolve from the enzyme but he's never seen it happen to anyone before. Lucky me! He said your body is constantly regenerating HA so my skin should return to normal but it could take a year. I asked him if he really thought it was possible for my skin to come back considering it has already been 5 mos but he told me to give it 7 mos more. He said that's why they don't do miso therapy anymore (injecting an enzyme that dissolves fat) - because the fat/tissue eventually regenerates. So I'm really doing my best to put this out of my mind for another few mos and I'll see what happens after the year is up. Of course, it's easier said than done. I still have to look at myself in the mirror every day and catching my reflection in the sunlight is less than ideal. I have to believe it looks far worse to me than to anyone else. How are things going with you? Are you seeing any improvement? How long has it been?

Hiya Beth - I am so glad to hear that your botox situation seems to have finally resolved! Sad to say no real good news here and the mirror is still my enemy. It has been 33 weeks, so more than 8 months, since my botox disaster and the nightmare drags on. I tooks your good advice and I try not to think about it every second of every day even though this is hard. Your 11-month time frame gave me a little glow of hope that I still have a way to go and I might not be stuck with this horror face forever. So thank you very much for that. My face now looks a bit better when it is at rest because the muscles that were flattened out over my cheekbones have started to plump back up but my face still looks god-awful when I smile or make any facial expression. I also still have the puffy, wrinkled bags under my eyes and I despair that these horrid additions to my face will ever leave me. Please read the latest two reviews on hyaluronidase. One poor woman from the UK who had Voluma (thick version of Juvederm) dissolved with hyaluronidase all over her face describes her face as having 'melted' because of it. I feel sick for her. I had a massive rant under both of the reviews about the irresponsibility of doctors asserting that hyaluronidase doesn't cause any damage to natural tissue. The experiences of some RealSelf members (including you and I) clearly shows this is not true. As to your situation, I can't believe that your doctor thinks that you might have to wait another 7 months for the indent to come out of your face. I particularly love your doctor's conditional admission about hyaluronidase damage - it is 'technically possible' but he has 'never seen it happen to anyone before'. Maybe he should have told you it was 'technically possible' before the injection??! And hang on a minute - if he has never seen it happen, then how did he come up with that time frame of another 7 months??! That makes no sense. If I remember correctly, you consulted with 3 prominent doctors before deciding to dissolve the restylane and they all said that hyaluronidase does not cause tissue damage. Yet now it seems that your doctor is willing to admit that it can because it actually happened to you. Just excellent. Funny that your doctor should mention MESOTHERAPY, too. Guess what enzyme is used in mesotherapy? Yep - HYALURONIDASE. Google it. Guess what purpose hyaluronidase serves in mesotherapy? It is used to break down the connective tissue bands that create the dimpled appearance of cellulite. Hmmm... in a different context when not related to cellulite (for example dissolving filler in the face), breaking down connective tissue bands sounds suspiciously like another way of saying HYALURONIDASE CAUSES TISSUE DAMAGE. Honestly, this is so absurd that I am almost laughing. Keep us updated on how you are doing and I wish you the best of luck, Beth. Cheers, K

Hi again Beth - I read your comment again and I retract my snarky comment that your doctor should have told you it was 'technically possible' for hyaluronidase to cause damage to natural tissue before the injections because I see you have gone to a new doctor. I assume it is not the same one who injected the hyaluronidase. But I stand by the rest of my snarky comments! I note that hyaluronidase is down to 8% who say it is 'worth it'...

My mistake again (tired!) - still holding steady at 13% worth it.