Fast facts

Sculptra


What it is: Permanent dermal filler (cosmetic injection) to restore facial fullness.


What it addresses:

Sculptra is US FDA approved for restoration or correction of the signs of facial fat loss (lipoatrophy) in people with human immunodeficiency virus.

Sculptra is used "off label" to restore facial fullness and to treat:

- Nasolabial folds
- Sunken cheeks
- Deep wrinkles
- Nose humps
- Facial creases


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Question

What can I do about Sculptra lumps?

Some 5 years ago I had NewFill (Sculptra) for smile lines and hyaluronic for my lip line. Some 2 months after, I started to get hard painful lumps, which I have been told are granulomas. I went back to the person who did the injections and he gave me 3 steroid injections. They broke the lumps down but seem to be more little ones and they seem to be worse again, almost like they're growing as I can notice them under the skin.

Can I get IPL or heat treatment Thermage to break them down? If I have steroid injections, what strength do I have and how many can have?

Heather, U.K.


Asked by: Anonymous

Answers (2)

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1
September 19, 2008

Sculptra Lumps

Dear Heather:

The sculptra lumps, or papules, that you describe are one of the complications with this product.  Sculptra is a synthetic poly-L-lactic acid.  If it is not laid down evenly, if it is too concentrated, if it is not put deep enough, or laid over a dynamically moving muscle or in skin that is too thin, papules are possible.  I have worked with this product for nine years and did the FDA study with my partner.  We now rarely see papules due to change in technique and dilution. 

If you have a papule this is how you treat it. 

First, your physician should use massage daily in the area if it is a recent pasule.  This is if it occurs immediately after injection (the first week or so).  If it is a nodule that has formed months after, have your physician use subcision.  This is when they take a small needle and physically cut it up.  Then they will flush the area with normal saline and inject a steroid.  If this doesn't work it may be injected with a mix of steroid and 5-FU.  Next, if there is still not a satisfactory result, you may start on a one month course of oral prednisone, as well as Doxycycline. 

Your physician may contact me via the "Request more information" form in my RealSelf.com profile if he would like more help in this area.

The other expert in this area is Dr. Danny Vleggar in Geneva and in Paris. 

Gail Humble MD

2
May 28, 2008

What to do about Sculptra (NewFill) lumps

Arnold W. Klein, MD
Arnold W. Klein, MD
Board Certified
Dermatologist

What you describe indeed sounds like a foreign body granuloma, which can occur at any time following the injection of synthetic or non-biologic agents. I am not a proponent of synthetic agents such as Sculptra, Artefill, Radiesse or silicone for this very reason.

In the medical literature, there are many reports of delayed foreign body granulomas; in one report with PMMA (Artefill/Artecoll, which is Plexiglas!), up to 12 or 13 years following the injections!  The reasons this can occur is that you are injecting something foreign into your body and the human body has a very sophisticated immune response. When it sees something as a foreign invaider, it creates a complex reaction to try to get rid of it, and the result is the granuloma which you describe.

The reason it seems to keep coming back is that as long as the foreign agent is present, the body can continue to cause the reaction in which it tries to wall off or encase the foreign body. These are the lumps you feel and or see.

Injectable steroids can help minimize this, but as you note, often you must continue to inject the steriods which can cause problems of its own. Some people seem to have success with this while others do not. Unfortunately, the only way to eliminate this immune reaction is to remove the reactive agent, something that is very difficult to impossible to do with Sculptra, Artefill, Radiesse, and silicone.

The IPL, "heat treatment" or Thermage that you describe will not help and should be avoided.  I would suggest seeing a specialist in your area who sees many such foreign body reactions who may be able to help with steriod and other injections to try to minimize this, but truly the best piece of information that I can give you is to remember that "a good offense is the best defense!" 

Always research the agents that you allow to be injected into your face, and this means going to medical web sites and reading about their safety; ask questions.  Permanent or synthetic agents should not be used for this very reason. They are foreign substances that can and do cause foreign body reactions.  Permanent agents can cause permanent problems! It is much better to use biologic agents such as collagen and hyaluronic acids such as Restylane and Juvederm.

While they are not permanent, when used by highly skilled injectors, they can last a year. In my practice, I routinely get these to last about a year, in some cases, I have had it last more than a year. And while it is true that they are not permanent, it is also true that they do not cause permanent problems either.

So please remember: Sculptra, Artefill/Artecoll, Radiesse and silicone are synthetic, non-biologic agents which can and do cause the foreign body granulomas from which you have suffered. It is very difficult and sometimes impossible to effectively treat these reactions, so when it comes to your face, less is more and never use a synthetic agent.

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