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I agree that the best non-surgical treatment is to use fillers like restylane, perlane or juvederm to support the corners of the mouth and below the corners if there is volume loss. If you are a person who grimaces or grinds their teeth while you sleep, you may have a more active muscle pulling down the corners of your mouth that can be treated by injecting a very small amount of botox or dysport to relax the muscle and soften your lower face. Its important to look carefully at each person's natural expressions and to personalize your treatment suggestions. I am sure others agree that we have to look closely at your expressions and anatomy before providing the best options for your care. I hope this helps!
Botox can relax the muscles that pull down the corners of your mouth. However this is usually very subtle. Fillers such as Restylane and Juverderm can make a big difference in lifting the corners of your mouth and the results are much more rewarding.
Botox can help bring the corners of the mouth up. Fillers such as Restylane, Juverderm, and Radiesse are also frequently used to bring up the corners.
We correct downturned corners of the mouth with filler and have great results. This procedure really makes a huge difference in overall appearance, and often we have a good amount of product left to correct other lines in the face.
I agree with the other doctors on this thread that Botox injections in the DAO muscle at the corner of the mouth can make a very noticeable improvement in downturned mouth corners. Caution must be used in this area, however, to avoid a crooked smile appearance. I also routinely place fillers such as Restylane or Juvederm in this area for best results. Good luck