Fillers, like JuveDerm, can cause some discomfort upon injection. Certain areas may be more painful, such as injections around the mouth or specifically in the lips. Nerve blocks (like a dental block) can take away much of this discomfort. There are a couple of ways to do this; an infraorbital plus mental block for injections around the mouth, or a sulcus-mucosal block for lip augmention. Sometimes the blocks themselves can cause a bit of distortion of the area, so some injectors try to get patients comfortable with a combination of topical anesthetics as well as using the formulations of fillers that already contain pre-packaged lidocaine (JuveDerm XC or Restylane-L) before going right to a block. But, patients can certainly ask for a nerve block right from the outset.