Proper preparation of Botox for injection

Ran Y. Rubinstein, MD answers: How much saline do you put into the Botox bottle

so that if you use a insulin syringe, the recnstiuted Botox is correctly reflected by one unit on the insulin syringe.

Ran Y. Rubinstein, MD
4 months ago

Allergan recommends mixing 2.5 cc of saline per 100 units of Botox.

There is a wide range of what doctors use--anywhere from 1 to 4 cc per 100 units. I think what is more important in achieving the results you desire is

  1. Skill of injector--who is injecting you?
  2. Make sure using real Botox
  3. Make sure it isn't watered down
  4. Make sure fresh Botox

Good luck!

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A: Botox bottle and saline

Steven Wallach, MD
4 months ago

Every doctor varies his dilution of botox so that it works for them. I prefer to keep it fairly concentrated.  This usually means 2 cc's of saline so that I get about 50 units per 1 cc syrringe.  Others double that number.

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A: How is Botox diluted

Ronald Shelton, MD
4 months ago

Whether the physician dilutes the Botox powder with a diluent of 1, 2, 2.5 or 4 ccs of saline, the important variable which determines your result, is the total number of units given. If doctor B uses a 2cc dilution they will have to give twice the volume of diluted Botox to create the same effect as doctor A who uses a 1 cc dilution. Both doctors will have administered the same number of units! If the dilution is excessive, then the larger volume might make the Botox travel via gravity or spread of fluid to surrounding areas and there might be an affect on muscles that were not targeted.

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