How long do different wrinkle fillers last?

In general, other respondents hit most of the points. I wanted to add that fillers in the lips (mainly the HAs) won't last as long as the same filler placed in the nasolabial folds or cheek area. The longest area of duration is around the eye as several docs have suggested.

The theory is where there is more muscle movement, there is faster degredation. I find the nasal injections last about the same time as the nasolabial injections, maybe slightly longer.

There are also rapid metabolizers of HAs. For unknown reasons, some people chew up the filler faster than the general population. I've also heard of some rapid Radiesse metabolizers discussed at some meetings. If you think you're a rapid metabolizer of HAs then try Radiesse.

A new filler called Evolence will be FDA approved very shortly. It is a cross-linked collagen and will be labelled as lasting about 6 months but will probably get approval for saying 12 months after more studies are submitted. It can't be put in the lips, although a second form of it, called Breeze, will be able to.

The length of a filler depends on the person, location, and product.

Metabolism and absorption of fillers varies from person to person. Location of the filler can also affect its length. For example, fillers placed in the tear trough will last much longer than a filler placed into the lips. The more mobile the area, the faster the product will be absorbed.

Product selection will also have an impact. Most hyaluronic acid gel fillers (such as Juvederm, Restylane and Perlane) last roughly six months. Radiesse, which is made of calcium based microspheres, usually lasts around 8-12 months. Sculptra stimulates collagen and last for about 2 years.

The newer “dermal fillers” have virtually replaced the older injectables, such as collagen, whose treatment effects lasted only about 3 months. With the newer fillers, such as Restylane, Juvederm, Radiesse, Sculptra, and others, you can get a smoother and more volumized facial appearance that can last anywhere from 6 months to 1 year or more.

In sum, dermal fillers are a great way to add volume to the lips and to smooth out lines around the mouth, nose, chin, or elsewhere on the face. They work very well and most folks are happy with the results.

Restylane and Juvederm are hyaluronic-based products and last about 6 to 9 months – these are generally the most commonly used cosmetic fillers. There are some newer fillers that promise somewhat longer lasting results, however, with a longer-lasting product comes more cost and increased risk of side effects.