Horribly Lumpy Lips from Juvederm. Had Hyaluronidase Injection-looks Even Worse. Could They Be Permanently Ruined?

Give it a few days, sometimes a second hyaluronidase treatment is needed to break down all of the injected hyaluronic acid (the stuff Juvederm is made of).  I have had to use hyaluronidase many times for unpleasant filler outcomes, usually done by inexperienced injectors.  All have resolved very nicely.  I have not seen any permanent damage.  Actually, even if you do nothing the Juvederm will slowly go away, of course you have to live with the lumps for months so I think hyaluronidase was the right choice.

Most of my hyaluronidase patients went on to have the Juvederm or Restylane reinjected with very good results.

The injector's experience is everything. The best thing about non-permanent fillers is that thay are not permanent. Be patient and select your injector with care.

No, it would be very unlikely that any permanent change would occur, to your lips, after Juvederm Lip augmentation even if hyaluronidase was later injected to dissolve some of the Juvederm.  The hyaluronidase just wasn't able to dissolve all of the Juvederm or do it evenly which is why, IMHO, if at all possible I'd suggest leaving the temporary fillers alone until they dissolve on their own.