Testosterone therapy in transgender men results in several masculinizing changes, including a reduction in breast size due to the shrinkage of glandular and fatty tissue. However, testosterone does not significantly affect breast skin, so while the tissue may become smaller and firmer, the skin often remains loose or saggy. This can result in a deflated appearance, particularly for individuals with larger breasts, as the skin doesn’t tighten to match the reduced volume. Additionally, testosterone increases muscle mass, contributing to a more masculine chest contour, and stimulates the growth of body and chest hair, further enhancing a male appearance. While testosterone can produce some breast changes, it is generally not enough to fully achieve a masculine chest for individuals with larger breasts, as the skin may remain excessive or saggy. Most individuals with significant breast tissue or skin laxity will require top surgery, such as double incision or keyhole surgical approach, to remove excess tissue and skin and create a flatter, more defined chest. The effects of testosterone take time, often requiring months to a year for noticeable changes, and results can vary depending on factors like skin elasticity and initial breast size. In most cases, a combination of hormone therapy and top surgery is the most effective approach for achieving a masculine chest. I will mention that in my practice, we do not have a requirement for hormones to have surgery, but any CHANGES (starting/stopping) should be done 3-6 months before or after the planned procedure, and not peri-operatively to avoid fluctuations. It is important to consult with a qualified gender-affirming breast surgeon who can customize your surgical plan with the best technique based on your individual anatomy and goals. Be sure to ask about experience and options for surgical techniques (such as incisions, liposuction, nipple reinnervation). Krishna Vyas, MD, PhD, MHS Harvard, Hopkins, & Mayo Clinic Trained Aesthetic Plastic Surgeon New York, New York