Only certain types of filler injections have lidocaine in them, making the injection less painful. The most popular products, however, do not. For nasolabial folds, eyelids, lip corners, and marionette lines I always use a "dental" block. These areas are well anesthetized with a small local anesthesia block. This block takes effect almost immediately. I like to ensure my patient's comfort because it is critical for precise injections. Other areas, such as the frown line or the lip itself are not well covered by the dental blocks. In those instances I do use the topical cream, often in association with a formal block. The lips have too many nerves going to them to block completely. They are also very very sensitive. That is why I add the cream. Creams do work well, however, they have to be left on for a minimum of 30-45 minutes to be really effective, which is a lot of time for a patient to sit around and wait.