Topical hydroquinone is one of the most popular agents for bleaching the skin to reduce the appearance of conditions such as melasma or chloasma.
Hydroquinone Formulas
With Retin-A. Hydroquinone is frequently combined with Retin-A to enhance its bleaching effects. Due to the irritating nature of both of these agents, topical steroids are commonly added to minimize the inflammation. Hydroquinone (HQ) has a long history of safety when used properly, but should not be used when pregnant or in the process of conceiving.
With Sunscreen. Some hydroquinone formulas also contain sunscreen to help mitigate any visible damage (ie, recurrence of "sun spots" or skin discolorations) that might occur as a result of sun exposure while using hydroquinone.
Different Concentration Levels. Hydroquinone products are available over the counter in 2% concentrations, which are generally weak, but useful in mild cases of hyperpigmentation. As a prescribed medication hydroquinone is commonly prepared in 3-7% concentrations.
Hydroquinone Safety
In 2007, the FDA generated alot of negative publicity when it considered recalling the product due to concerns with cancer and ochronosis (a pigmented condition of the skin). The reports were sufficiently rare that the FDA abandoned the recall.
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