Disappointed with Botox

have had the same experience with Botox. The first couple of times I was injected it worked fabulously. Then it became less and less effective. My doctor thought it might be a bad batch and each time she did injections from that time on she used a new, fresh bottle and still no results. She then contacted Allergan who said this was impossible either the botox had not been stored properly or her technique was wrong. Of course I was the only one of her patients to have this happen. Allergan then sent one of their reps to witness the injections as this doesn't happen to verify the injection method, massive amounts of botox were used and three weeks later the rep came back to see the results and confirmed that there was nothing wrong with the method and that I had indeed become a non-responder. From then on my doctor has been in contact with Allergan and their medical department in order to examine this further. My case is being reviewed in order to determine why this is happening. Therefore my advise would be to have your doctor contact Allergan as this is not supposed to happen and apparently has not happenned to anyone else. The more people who come forward with this the more seriously Allergan will respond in examining why and how to overcome this. Apparently Myobloc may work??

What exactly is Myobloc? I have read other reviews on this site about unhappy customers. One woman found she had been exposed to Botulism before and that was why it wasn't working for her. Your doctor sounds like he/she went all out to figure this out. I feel like I get any sympathy, the doctor looks at me like I am nuts. He thinks the area looks good. I suppose it is less noticable than prior to the injections but the people in his office have completely smooth foreheads. It's really frustrating.

Myobloc is apparently a competitor to Botox used more widely in Europe. It is the botulism type B rather than A (Botox). Allergan is very opposed and says that it is very unstable. I'm in Canada where it has not yet been approved, however I've spoken with a clinic in Syracuse NY who uses it. Their comment is that it doesn't last as long as a successful Botox injection, no more than 3 months but you see the results within 48 hours. My doctor has been great, she is very concerned that if this is happening to me it will happen to others and if Allergan is putting this out as a no fail solution it could be real bad press down the road as more people spend money they may not be able to afford on a drug that doesn't work. The deeper we dig into this though I get the feeling that Allergan would rather sweep these cases under the carpet, as their claim is that this doesn't exist and it is impossible. We will, see I had a meeting with one their doctors this week. I should be hearing more in the next few weeks.

There are a couple of things that should be mentioned here: 1) Hawry1 - I'm surprised at the response that you got from Allergan. From the medical use of Botox for conditions such as neck muscle spasm and facial twitching we know that in some reports up to 10% of people will develop clinically significant antibodies to Botox. This means that your body develops antibodies to the protein to make it not work like it should. This has been known for some time and is a known occurence with Botox cosmetic. In some patients this means that increasing doses of the medicine are needed for the same result and in other cases the medicine does not produce the desired results at all. 2) Julianna - Without seeing exactly what you are talking about I can't comment specifically on your case but a word of advice. In patients who get Botox infrequently, you will notice that it does not last quite as long as you think. If you get repeated injections at the first sign of muscle activity you will notice that the Botox appears to last longer, and in some people several months or even a year. This is due to 'disuse atrophy' of the muscle. Even though the Botox has worn off, the muscles have been so weakened from not being used that they cannot produce the wrinkling that you can see for some time. 3) As for fillers for the wrinkles. Wrinkles can be caused by two different things - muscle activity or tethering of the skin to underlying structures - or both. For some people, fillers (such as Restylane and Juvederm) are a more desireable option while for others both Botox and fillers must be used for the best result. Other more permanent methods of repairing certain wrinkles are possible. For lines between the brows, removal of the muscles which cause the lines and procedures to break the tethering bands are possible which give good long term results.

AliGrace, Thanks for your inquiry. As I mentioned there are two reasons for lines between the brows - activity of two muscle groups, the procerus and the corrugator, or tethering of the skin to the deeper structures. During brow lift procedures, the procerus muscles are often cut to help prevent movement of the brow area. For a more complete denervation of the area, removal of the corrugator muscle can be achieved through the same incision that an upper eyelid blepharoplasty is performed. There really is no medical term for the procedure, more of a description. The biggest risk involved with corrugator resection is numbness of the forehead which could be permanent. As for removing the tethering, there is a relatively new procedure using the Surgiwire device (made by Coapt systems). The device undermines the skin then either fat, filler, or fascia is placed in the undermined area to create a permanent raising of the area. This is a good alternative for people who want a more permanent solution than temporary fillers can provide.