Scared About Reaction of Hyaluronidase with Own Collagen

Hi Mishka,

Sorry to hear about all the problems you're having with your doctor.

This related thread might help answer your question: What are the risks of injecting hyaluronidase?

Best of luck with your recovery.

Hi Mischka - as I understand it, hyaluronidase has only been used to dissolve filler since about 2006. It is an 'off label' use, meaning it is not FDA approved for this purpose. Hyaluronidase is used in various surgeries (like opthalmic surgery) to assist in the dispersion and delivery of other drugs. This is its 'on label' use. As to affecting your own tissue, lots of your own skin is made up of hyaluronic acid (like dermal filler). The difference is that dermal filler is 'cross-linked' whereas your own hyaluronic acid is not. Some doctors say that hyaluronidase injections only dissolve the filler, while other doctors say it can affect your natural tissue as well. Other doctors believe that hyaluronidase affects your natural tissue but then causes a positive collagen reaction because your body is responding to trauma. There is absolutely no consensus among the medical profession about the effects of hyaluronidase on natural tissue. I did have filler in my tear troughs dissolved with hyaluronidase and the swelling was horrendous. I think it did affect my natural tissue but that is just my experience. Hyaluronidase (vitrase, hydase etc) does come in different strengths so you really need to find someone who is very experienced with this product and knows what they are doing. Good luck with that(!) Hope your problems resolve themselves soon. Cheers

Hiya I had 3ml of Hyaluronidase injected under each eye yesterday by a well respected occular consultant. This was after a complete inept GP overfilled my tear troughs and then dissolved some very unevenly. I was absolutely reassured by the consultant that there would be no damage to my own tissue and my mind was put at rest. My eyes did swell massively but most of the swelling has gone and there is no bruising at all. I am waiting (impatiently) for the rest of the swelling to go, its only been 24 hours and the swelling is only noticable in certain lights. The consultant was so appalled by the way in which I had been treated that he waived his fee and has written a letter to the GP who cocked it up to begin with, explaining what she had done, and what she had done wrong! He also requested that she give me my money back! what a star.....if I do choose to have my tear troughs done again, i'll be definitely going to him, the injectors technique is paramount to the end result. Hopefully my six weeks of hell will be at a complete resolution in a few days! Good luck

Yes is was 3ml under each eye! Seemed like loads and I looked hideous for about an hour but the initial swelling went dowm rapidly. He said that to make sure that all the Resty was dissolved the large amount was necessary. It was also mixed with other anti inflammatory stuff and something for the pain. Apparently hyalurondase is used in anaesthetics all over the face and body to help it spread. He explained this very clearly to me as I was sooo worried like yourself that I would end up ruining my skin. I am practically back to normal now. The stupid doctor who gave my hyal injections before gave me black eyes and caused divets and lumps as she clearly was not used to using it. One syringe for whole face sounds minimal to me but if I were you I would consult someone who uses this stuff all the time. I traveled 3 hours to see this consultant and burst into tears on the spot when he told me he was waiving his charge, I was so overwhelmed by his caring attitude and relieved that I was in capable hands at last. I think he was angry about the fact that there are inept idiots out there giving the proffession a bad name, I'd already emailed the woman stating how upset I was and unhappy with my appearance and she just ignored it! In complete contrast he told me if I'm not happy in a few days to go straight back but I have a feeling all going to be fine. I look so much better already than when I walked into his office yesterday! I hope you get yourself back to normal or get more happy with your appearance.....I would seek advise elsewhere perhaps if I were you. Good luck and let me know how you go on.

Hyaluronidase acid injection does interfere with your natural collagen. I received 5 injections to remove Perlane that I received 3 years ago! I had Perlane injected in my tear troughs to correct some simple dark circles that weren't even bad. I'm only 24 years of age and single... My face is not the same. I have indentations, and I can still feel some of the product in my cheek. I have lower eyelids, and I just look dead. I also noticed a change in my skin, skin atrophy in the orbital area. I don't know what happened. I just know that fillers are dangerous, and hyaluronidase injections to remove the product makes things worse, and will affect your natural collagen. Trust me, my skin is sagging, and i didn't have this before. PLUS I have like 5 creepy wrinkles and vein erruptions under my eyeslids just because of the product! The hyaluronidase just made it saggy, which I should have figured to begin with. Common sense.