What to Do About Sculptra (NewFill) Lumps and Granulomas

Steroid injections may help, although there are risks associated with multiple steroid injections such as possible fat atrophy.  I would encourage you to discuss with your physician the use of 5-FU as a possible treatment.   

More recent reports show that biopsy of these nodules caused by Sculptra or Radiesse are not true granuloma in most cases.  Artefill / PMMA crystals were proven to be granulomas on surgical resection specimen.  Sculptra nodules were a massive collagen reaction!  Currently, most of us are diluting Sculptra in larger volumes of bacteriostatic water (10ml) which for the most part results in NO nodules.  Currently we see rare cases of palpable but not visible nodules under thin skin, in cases of active autoimmune disease, and when patients forgot to massage for 5 minutes at a time for 5x/day for a total of 5 days.
The results from Sculptra and Radiesse are phenomenal, both fillers are cost effective, and grossly undermarketed by the respective companies.  
Treatment of Sculptra nodules:  Steroid injection with caution.  If they are resistant to steroids, in rare cases, 5 FU has been effective.
Best wishes,
Dr B