What to Do About Sculptra (NewFill) Lumps and Granulomas

Five years following this treatment and you still have nodules means that it is most likely either a foreign body granuloma or deep scar. Steroid injections sometimes help but there can be some side effects especially with multiple injections (fat atrophy, hypopigmentation, etc).

Although FDA off-label usage you might want to ask your doctor and research the use of 5-FU - I have used it effectively for these problems and have not seen complications thus far even after multiple injections. See a Plastic Surgeon or Dermatologist who has experience in these problems.

The best option for Sculpra nodules and granulomas is prevention through proper mixing, injection technique, patient selection, and post-injection care. Once nodules or granulomas develop, steroid injections, massage, saline infiltration, or surgical excision are all options. These treatment options will depend on the patient and the problem area.
All the best,

Hi Anon,

Sorry to hear about your adverse events following your Sculptra injections.  The best current treatment to help dissolve the nodules is injection of them with a mixture of 5 FU (off label use), Kenalog 10, and lidocaine.  We have seen marked improvement in patients from other practitioners who developed nodules.  Good luck and be well.

Dr. P