Threads for lifting downturned lip corners? (Photo)

A downturned smile or permanent frown can be improved with a combination approach, including neuromodulators (such as Botox, Dysport, and Jeuveau), injectable fillers, and radiofrequency skin tightening treatments such as Thermage or Venus Legacy. I recommend getting a formal evaluation with an experienced cosmetic dermatologist to develop a treatment plan that works for you. Best, Dr. Emer.

I cannot tell from your photo how much filler or fat implants in your cheeks would help the corners of your mouth, but that is always where I start. From there, a properly placed filler around the mouth can help the corners. Threads are  still a viable option and I have used a lot in your age group. I just look at volume issues first.