What is the difference between between Aqualyx and Kybella? And how come only Kybella is FDA approved?

Question

What is the difference between between aqualyx and krybella. i know krybella is specifically made for bubble chin (but usead off-label in other areas) and that both treatments active ingredient is deoxycholic. do they work similair? or the same? and how come Krybella is FDA approved but not Aqualyx? i'm looking to use both in knees, thighs area as well as dubble chin. thanks for your reply

Jonathan Hall, MD · Answer

They work by the same mechanism, as both are forms of the same active ingredient.  Deoxycolic Acid is a molecule that occurs naturally in the body and helps us to breakdown and absorb fat in our diet.  When injected into the fat cell, it causes it to breakdown and be absorbed.  Only Kybella is approved for use in the US.  The approval studies targeted the fat under the chin, so that is the only currently approved use. Although this molecule could theoretically target fat anywhere, using it outside of the submental area is currently "off label" in the US.  The approval process is different in other countries, and the company that distributes Aqualyx describes using it in other areas as well.  But performing the studies to obtain FDA approval is expensive, and has not been done yet in the US.  I would recommend that you see a board certified plastic surgeon to see what may be best in your case.

Samuel Hetz, MSc, MD · Answer

Kybella (Belkyra in Canada) is the only FDA and Health Canada approved injectable treatment to treat submental fullness (double chin). The only area approved for it's use is the double chin area. Some physicians may be using it off label, however, at our clinic we stick to approved indications. All the best.

Kouros Azar, MD · Answer

You are correct. Both products are similar. However, only Kybella is FDA approved, but only for fat under the chin. This means that a lot of research has gone it to both it's safety and efficacy. Although surgeons are trying Kybella in other areas of the body, referred to as "off label" use, make sure to see a board certified plastic surgeon in your area with lots of Kybella experience to ensure that it is safe.Kindly,Kouros Azar

Michele S. Green, MD · Answer

Both are very similar.  However, Kybella is the only one that is currently FDA approved for injection in the US and I would recommend that you only have Kybella performed now by a skilled board certified physician.  Best, Dr. Green

Luis A. Cenedese, MD, FACS · Answer

Several fat dissolution injectables have been used successfully for years. Kybella has passed the FDA scrutiny as a safed treatmet.  Aqualyx and other products have been studied in countries outside the U.S.Please use this information when consulting in person with a Board Certified Plastic Surgeon.

Keith Denkler, MD · Answer

Aqualyx® is a compounded solution from the deoxycholate family so it is similar to Kybella.Aqualyx® can go through the US approval, but the studies are rigorous and expensive.Kybella is approved in the US for the double chin and can be used off label in other areas pending an exam.

What is the difference between between Aqualyx and Kybella? And how come only Kybella is FDA approved?

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