Can Tretinoin or Retin-A Correct Nasolabial Fold Lines?

Doctor Answers 4

Retin-A (Tretinoin) for Nasolabial Folds

Application of Retin-A (tretinoin) will cause reduction of fine wrinkles, mottled hyperpigmentation, and roughness in the skin. Tretinoin is not effective for deeper folds such as those seen in the nasolabial area. Fillers such as Radiesse are much more effective for the treatment of this area.


South Burlington Dermatologic Surgeon
4.7 out of 5 stars 12 reviews

Tretinoin cannot correct nasolabial folds

Tretinoin can improve very fine surface wrinkles, pigmentation and sun damage but cannot correct nasolabial folds.  For that you need a dermal filler like Perlane, Juvederm Ultra Plus, Radiesse or Sculptra. 

Emily Altman, MD
Short Hills Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

Retin A will not correct nasolabial folds

Retin A is a great topical treatment to minimize the signs of sun damage on the face (photo aging) but it does not correct or minimize nasolabial folds. Nasolabial fold should be treated with fillers such as Juvederm or Restylane.

Steven Hacker, MD
West Palm Beach Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

Wrinkle Improvement with Retin-A

Although the retinoids are quite good over the long-term in improving fine lines and wrinkles, they will not be effective for deep wrinkles such as nasolabial folds or dynamic wrinkles.  It is best to think of the retinoids as one part of a complete aesthetic solution. 

Joseph Campanelli, MD
Portland Facial Plastic Surgeon
4.5 out of 5 stars 8 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.