These are per my office's instructions, but we do change it a bit depending on when and why we used the Cosmelan 1. Nightly, before bed wash your face with a mild soap then apply a thin layer of Cosmelan 2 to the full face or the affected area. DO NOT WASH OFF. Leave on for 15 minutes, then apply Vitamin K over the Cosmelan 2 and gently rub into the skin. You may notice a slight peeling or flaking of the skin. You can also use the Vitamin K throughout the day if your skin is red or flaking, after a bit of cool water. So, really, check with your office! "This answer has been solicited without seeing this patient and cannot be held as true medical advice, but only opinion. Seek in-person treatment with a trained medical professional for appropriate care."