Titanium dioxide (CI77891) is a widely used pigment in various products, including cosmetics, sunscreens, and food. It is generally considered safe for topical use. However, there are some considerations regarding its safety: Form and Exposure: The primary concern with titanium dioxide relates to inhalation of its powdered form, which has been classified as a possible carcinogen to humans by the International Agency for Research on Cancer (IARC). This risk is associated with occupational settings where inhalation of dust could occur. Topical Application: When used in products like scalp micropigmentation, titanium dioxide is typically in a non-inhalable form and is applied directly to the skin. In this context, it is not considered a cancer risk. Regulatory Status: Titanium dioxide is approved for use in cosmetics and personal care products by regulatory agencies like the FDA and the European Commission, which consider it safe for use on the skin. In summary, when used in scalp micropigmentation, titanium dioxide is not considered dangerous or cancerous. The concerns primarily arise from inhalation risks in industrial settings, not from topical application. However, if you have specific health concerns, it is always a good idea to discuss them with your healthcare provider.