Can I take Spironolactone while I am on the Depo birth control shot?

Spironolactone is a medication often used off-label to treat hormonal acne. It's generally considered safe to take alongside hormonal birth control, like the Depo-Provera shot. However, as with any medication, there can be potential side effects or interactions, so it's important to discuss this with your healthcare provider.
Your dermatologist would be the best person to provide you with personalized advice based on your medical history and current medications. It's also recommended to consult your gynecologist or the healthcare provider who prescribed your Depo shot to ensure they are aware of any new medications you're considering.