Can I take Spironolactone while I am on the Depo birth control shot?

I believe I have very hormonal acne, and I have tried many topical creams, and nothing has worked. I think that I need to try taking something that will work from the inside out, as I have had acne that is deep under my skin that topicals can't reach. My dermatologist told me I can try Spironolactone, but I am not sure if it will be ok to take while I am on the Depo shot. I am 23 years old and have been struggling with acne on and off for the last three or so years.