What is the difference between having Radiesse vs Restylane filler for nasolabial folds? Which is better?

In my experience, all three of these products work beautifully for the nasolabial folds, also called the parentheses lines, extending between the edges of the nostrils and the corners of the mouth. The primary difference between them is that Restylane and Juvederm are have a shorter duration (~ 6-9 months) as compared with Radiesse, which can last up to 18 months or longer. I have not found a difference in duration between Restylane and Juvederm. The advantage of these hyaluronic acid (HA) fillers is that they can be dissolved with a simple injection of hyaluronidase in the unlikely event of a lump or asymmetry. Radiesse cannot be dissolved and is slightly more expensive at our center. I have not found a difference in the degree of bruising with any of these fillers. 

The volume line on nasolabial folds can be restored with the injection of fillers. There is no filler better than the other. The discussion of using Radiesse vs Restylane or Juvederm, will depend on the severity of the volume line. For this area there has been great advances and my preference is to inject Restylane Defyne or Refyne since the way they were engineered makes them more flexible which contribute to their natural look.

Hello,
Good question as both are good options.  However,we often are determining which is the best product for a patient if both are considered equally good.  This decision is based upon patient's age, condition, skin turgor, bone structure, and degree of need for correction.  For example, a patient that is over 40 with heavy laugh lines from aging  may do better with Radiesse for it's lifting/support quality.  Restylane LYFT does this as well, but we find Radiesse has a better "tug and hold" ability.  For a younger patient that only requires a mild correction, Restylane or Restylane LYFT may be appropriate.  
Referring back to your question as to durability and duration - we believe the most important factor is having enough product to reach your goals.  Oftentimes, a patient will not achieve their goals because their budget did not allow for full correction.  Be certain to discuss this with your injector so that your options are understood.