Radiesse is a dermal filler that is often used to restore volume to the face and hands. When hyper-diluted, Radiesse can also be used to improve skin texture and stimulate collagen production. The exact timing of when Radiesse will take effect can vary from person to person. In general, patients can expect to see results within the first week or two after treatment. However, it is important to note that the full effects of Radiesse may not be visible until several weeks after treatment as the collagen-stimulating effects of the filler take time to develop. The number of vials necessary to achieve a noticeable change with Radiesse will depend on the area being treated and the extent of volume loss. Your healthcare provider can evaluate your specific needs and recommend the appropriate amount of Radiesse for your desired outcome. In general, patients can expect to see more significant changes with larger amounts of Radiesse. It is important to note that Radiesse, like all dermal fillers, is a temporary solution and will eventually be metabolized by the body. The duration of results can vary depending on factors such as the area treated and individual metabolism. In general, Radiesse can last up to 12-18 months. It is always recommended to seek advice from a board-certified healthcare provider who specializes in cosmetic procedures to determine the best treatment plan for your specific needs and concerns. They can answer any questions you may have about the procedure and provide you with more detailed information about the expected results and recovery process. I hope this helps, best of luck !