Can Prednisone Affect Sculptra?

Sculptra helps your body produce collagen.  That is similar to the process of inflammation and for the several days you took the Prednisone, there may be less inflammation.  There may be less production of collagen by the fibroblast cells that make the collagen during this time, but the prednisone doesn't kill those cells, just inhibit them. Sculptra is a long term process and a week of reduction of its collagen stimulation, if that occurs from prednisone, should not prevent its ongoing effect.

While a prolonged course of prednisone immediately after Sculptra injection may potentially hamper optimal stimulation of collagen by Sculptra, it is unlikely that a low-dosed short course of prednisone 3 months after last Sculptra injection would have any significant impact. 

The short course of steroids that you have taken, well after the sculptra has done most of it's work, should not be any problem. This probably all represented changes in fluid retention during steroid use and loss of that after. 

By 3 months post your Sculptra treatment, you have had most of your collagen deposition completed from your treatment.  I would be more concerned if you had the prednisone within the first 4 weeks.   Also 5 days is a relatively short time, whereas a longer course might have more effect on collagen deposition.

Sculptra works by causing a immune reaction to the product.  This is the last thing you want a filler to do.In certain studies up to 50% of individuals injected developed lumps. So Prednisone stopped the Allergic reaction and also the affect of the agent.