Can Prednisone Affect Sculptra?

Sculptra helps your body produce collagen.  That is similar to the process of inflammation and for the several days you took the Prednisone, there may be less inflammation.  There may be less production of collagen by the fibroblast cells that make the collagen during this time, but the prednisone doesn't kill those cells, just inhibit them. Sculptra is a long term process and a week of reduction of its collagen stimulation, if that occurs from prednisone, should not prevent its ongoing effect.

While a prolonged course of prednisone immediately after Sculptra injection may potentially hamper optimal stimulation of collagen by Sculptra, it is unlikely that a low-dosed short course of prednisone 3 months after last Sculptra injection would have any significant impact. 

The short course of steroids that you have taken, well after the sculptra has done most of it's work, should not be any problem. This probably all represented changes in fluid retention during steroid use and loss of that after.