Medication for depression and anxiety - Will I metabolize meds better after surgery?

Question

I am a 27 yr old female. I have crohns and drug resistant depression and anxiety. I don;t seem to respond to low dose anything. I'm getting a gastric bypass. Will I metabolize meds better after surgery? I hardly sleep now and amber does nothing. I hope the lb loss helps me feel better and makes drug milligrams more level.

Reza Keshavarzi, MD, FACS, FASMBS · Answer

Hi Gregarious460892,
Thank you for reaching out and sharing your story. It’s clear you’ve been through a lot, and I want to first acknowledge your strength in seeking answers and pushing forward with your health journey.
After bariatric surgery, such as a gastric sleeve or gastric bypass, medication absorption does change. Because the anatomy of the digestive system is altered, certain medications may absorb differently &mdash; sometimes more slowly, sometimes less predictably. This can mean that some people need dosage adjustments after surgery, and in some cases, medications may actually work better once inflammation decreases, weight is lost, and overall metabolism improves.
For conditions like depression and anxiety, many patients do find that after weight loss surgery, improved sleep, reduced inflammation, and positive changes in energy levels and self-esteem can help support better mental health outcomes. However, it’s important to work closely with your psychiatrist and surgical team after surgery to monitor how your medications are working and adjust them as needed.
At Miami VIP Surgery, we specialize in personalized care before and after gastric sleeve and gastric bypass procedures. We’re proud to offer comprehensive coaching and support throughout your journey. If you’d like to learn more about what to expect after surgery, feel free to visit our website.
Please know you’re not alone in this. Many people with Crohn's disease, depression, and anxiety have gone on to feel significantly better after surgery &mdash; physically and mentally. It can be the start of a powerful new chapter. We’re rooting for you every step of the way.
Wishing you strength and healing ahead,
Dr. Keshavarzi

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