Should People with Allergies Use Dysport an Alternative to Botox?

Dysport uses human serum, abobotulinumtoxinA and lactose. Is this a better alternative than Botox?

Doctor Answers 9

Patients who are resistant to one products may be successfully treated with the other.

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I have a number of patients who are resistant (could be they have antibodies) to Botox who are successfully treated with Dysport.  This is also true for patient resistant to Dysport who are successfully treated with Botox. 

Salt Lake City Dermatologic Surgeon
4.2 out of 5 stars 18 reviews

Botox vs Dysport in people with allergies

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Botox (onabotulinumtoxin A) has the following ingredients:

  • botulinum toxin type A produced from fermentation of Hall strain Clostridium botulinum type A
  • casein hydrolysate
  • yeast extract
  • human albumin

Dysport (abobotulinumtoxin A) has the following ingredients:

  • botulinum toxin type A
  • human albumin
  • lactose
  • Dysport may contain cow’s milk protein.

If you are allergic to any of the ingredients in one of these products, you should not use it.  The makers of these medications also warn that if you have severe allergies to multiple products or medications, caution is advised in using these products.  That is because if the person is allergic to multiple substances, they may develop allergies to other products easier than a person who does not.

Otherwise, if you have allergies that are not part of the ingredients in these products and if you don't have a history of multiple allergies, there should not be a problem using them.

Emily Altman, MD
Short Hills Dermatologic Surgeon

Allergies and Botox and Dysport

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If you're asking if patients who have never had botox or dysport, but have a history of being allergic to things, such as hay fever, asthma, antibitoics, etc. should try one over the other botulinum toxin, they are relatively similar but possibly less free protein load in Dysport.  If someone is truly allergic to Botox, possibly they wouldn't show a reaction to Dysport but Allergic reactions to Botox are so rare that most physicians have never seen such a reaction. If this is a possiblitiy with you, then you should see an allergist who can test you to the products if the physician who is about to inject you can supply the allergist with the chemicals. There is a chance that someone can become allergic to an ingredient in the liquid that the Botox or Dysport is mixed with prior to the injection.  This has to be investigated as well. Some doctors use preserved saline and the allergist may have to test this as well and then if this is the cause, botox mixed with preservative-free saline might not induce an allergy. If there is an immunologic reaction wtih antibodies, then changing to another serotype might make sense, but none exist now (dysport and botox are both serotype A botulinum toxin) and the prevalence of immunity to botox is extremely rare.

Ronald Shelton, MD
Manhattan Dermatologic Surgeon
4.9 out of 5 stars 39 reviews

Allergies and Botox/Dysport

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I have been injecting Botox for nearly 25 years and was part of the FDA trial for Dysport. I've never seen an allergic reaction to either product. However, that being said, if you are allergic to any of the ingredients - you need to see a full listing from a physician - I would not use the product. Additionally, your injector should be able to inject a very tiny amount of the product for you as a spot test to see how you respond. I've never had to do this before, but it can be done easily if you have concerns about allergies.

Allergy to botox/dysport

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I have never seen an allergc reaction to either but would not use something if you have a KNOWN allergy to any of the ingredients. Better safe than sorry.

Jo Herzog, MD
Birmingham Dermatologist
4.8 out of 5 stars 20 reviews

Not every allergy is created equal.

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The answer here depends precisely on the nature of one's allergy.  Your question seems to be hypothetical.  Occasionally people without out allergies harbor the belief that it is a good idea to avoid drugs to which others have allergies.  If you do not have a known allergy to the ingredients of these agents, then it really does not matter which of these drugs you have.  If you have an actual allergy, I recommend that you consult your potential doctor.  You may actually need to be patch tested to determine if a product is safe for you.

Kenneth D. Steinsapir, MD
Beverly Hills Oculoplastic Surgeon
4.9 out of 5 stars 26 reviews

Botox and allergy

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Both Dysport and Botox have human albumin in it. There is no contraindication for patients with egg allergy. Dysport carries a contraindication for patients with milk protein allergy (not lactose intolerance). Hope this clears things up a bit.

Peter T. Truong, MD
Fresno Oculoplastic Surgeon
4.9 out of 5 stars 42 reviews

Botox and Dysport For People With Allergies

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Either product is fine.  A neurotoxin should not affect your allergies unless you are allergic to the material itself, which I have never encountered since I started injecting Botox in 1995, or have had an adverse reaction to it.

Sheri G. Feldman, MD
Beverly Hills Dermatologist

Use of toxins in people with allergies

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 It depends on what your allergies are. People who have allergies to eggs should not use Botox and people who are allergic to milk should not use Dysport. There should be no difference otherwise.

Rosalyn George, MD
Wilmington Dermatologic Surgeon
4.4 out of 5 stars 12 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.