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Unfortunately, despite the marketing hype to the contrary, there are currently no creams, lotions, or serums that can take care of deep folds. At best, prescription strength retinoids, like Retin A and alpha hydroxyacids, like glycolic acid, can help for fine lines--when used regularly for months.A volumizing filler is the way to go for nonsurgically treating a deep nasolabial fold. My filler preference in my Upper East Side Manhattan practice would be Radiesse combined with Perlane L. In my Israel satellite facility where a greater number or regulatory agency approved fillers and volumizers are available I would opt for Radiesse combined with Restylane SQ. A treatment generally takes about five minutes to complete and the results typically engender an immediate "Wow!" response. So, if the problem is only a nasolabial fold, even in a young person such as yourself, forget the creams and lotions, and seek consultation with a board certified aesthetic physician with experience and expertise in the use of all kinds of injectable fillers and volumizers.
Retin-A is great for the skin! It willstimulate cell turn over and collagen production however; it does not effectivelytreat nasolabial folds. Retin-A will expedite cellturn over. The rapid cell turn over reduces the number of layers of cells onthe skin bringing new healthy skin to the surface. Overtime Retin-A can improvetone, texture, acne, and the appearance of fine lines.The best way to treat a fold is withfiller. Without a picture it is difficult to say what might be best for you. Ifthe fold is due to volume loss in the cheek it would be best to treat that areato improve the fold below. Because of your age it may be possible to just treatthe line.It is important to consult with a BoardCertified Dermatologist to see what the best option for you is. For more information click on link below:
Unfortunately, Retin-A will not help the depth of furrows of the nasolabial folds, although it has many other benefits.Pellevé can tighten the skin and help with this problem.
In general Retin-A is a great cream to use early on to help to build collagen, even out skin tone, and help texture of the skin and fine lines. Even with consistent Retin-A use at the right potency it can take several months to correct fine lines. However, I would not expect Retin-A to completely reverse or make a visible difference in a deep nasolabial fold. For this you may want to consider a hyaluronic acid dermal filler such as Restylane or Juvederm. With the right injector and correct anesthetic preparation the injections can be relatively painless and can give you immediate improvement!
It sounds like you’re having a “retinoid reaction”.  Clinically it takes about 3 weeks for skin cells to adapt and build a tolerance to the use of a retinol. If you feel that your skin is reacting far too much, cut back the use of the retinol to twice a week for several weeks and add in an...
After the expiration date most medications will lose some of their potency.  It would not be dangerous to use but may not be as effective. 
I am not surprised that some people become depressed while using Retin A. They probably were also running, or eating broccoli, or break-dancing, or living in Cobleskill. This does not mean that Retin A, running, eating broccoli, or living in Cobleskill cause depression.  Many times things...