Unfortunately, despite the marketing hype to the contrary, there are currently no creams, lotions, or serums that can take care of deep folds. At best, prescription strength retinoids, like Retin A and alpha hydroxyacids, like glycolic acid, can help for fine lines--when used regularly for months.A volumizing filler is the way to go for nonsurgically treating a deep nasolabial fold. My filler preference in my Upper East Side Manhattan practice would be Radiesse combined with Perlane L. In my Israel satellite facility where a greater number or regulatory agency approved fillers and volumizers are available I would opt for Radiesse combined with Restylane SQ. A treatment generally takes about five minutes to complete and the results typically engender an immediate "Wow!" response. So, if the problem is only a nasolabial fold, even in a young person such as yourself, forget the creams and lotions, and seek consultation with a board certified aesthetic physician with experience and expertise in the use of all kinds of injectable fillers and volumizers.